ArticleCell host & microbe2021
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
Open access · greenAbstract read
In one paragraph
Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 3 pooled it
46.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 3 syntheses or guidelines pooled it, 287 citations in OpenAlex.
- Global research trends in enteric nervous system and gut microbiota: a bibliometric analysis (2005-2025).Frontiers in cellular and infection microbiology · 2026Pooled it
- Gut microbiota bridges dietary nutrients and host immunity.Science China. Life sciences · 2023Pooled it
- Gut microbes in cerebrovascular diseases: Gut flora imbalance, potential impact mechanisms and promising treatment strategies.Frontiers in immunology · 2022Pooled it
- Trial
- Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling.Gut microbes · 2026Review
- The gut microbiota-tryptophan metabolism-immune axis in inflammatory bowel disease: Mechanisms and therapeutic prospects.Human vaccines & immunotherapeutics · 2026Review
- The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- TRPA1 Channels as Multimodal Environmental Sensors: Structure-Function Insights From Aquatic Organisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Whole-brain, all-optical interrogation of neuronal dynamics underlying gut and vascular interoception in zebrafish.Nature communications · 2026Article
- Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Review
- Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex differences inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Decoding the Gut-Fat-Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies.International journal of molecular sciences · 2026Review
- Gut distension evokes rapid neural dynamics in vagal and hindbrain populations of larval zebrafish.iScience · 2026Article
- From Epithelial Sensing to Visceral Pain: Neuropod and Enterochromaffin Cells in Gut Neuroepithelial Circuits.International journal of molecular sciences · 2026Review
- Article
- The gut-joint axis in osteoarthritis.Nature reviews. Rheumatology · 2026Review
- From diet to hypothalamic dysfunction: Neuroanatomical and hormonal integration of the microbiota-hypothalamus-adipose tissue axis.Reviews in endocrine & metabolic disorders · 2026Review
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
122 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
16 authors at 4 institutions in 2 countries.
Lihua YeDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Munhyung BaeDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chelsi D CassillyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Sairam V JabbaDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Daniel W ThorpeFlinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Alyce M MartinFlinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Hsiu-Yi LuDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.
Jinhu WangDivision of Cardiology, School of Medicine, Emory University, Atlanta, GA 30322, USA.
John D ThompsonDepartment of Cell Biology, Regeneration Next, Duke University School of Medicine, Durham, NC 27710, USA.
Colin R LickwarDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Kenneth D PossDepartment of Cell Biology, Regeneration Next, Duke University School of Medicine, Durham, NC 27710, USA.
Damien J KeatingFlinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Sven-Eric JordtDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Rodger A LiddleDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Department of Veterans Affairs, Durham, NC 27705, USA.
John F RawlsDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: john.rawls@duke.edu.
Duke University · USFlinders University · AUHarvard University · USEmory University · US
Funding
Identifying genes required for digestive physiology and lipid metabolismR01DK093399 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, John F Rawls · 2013 to 2026
$7.6MLeveraging zebrafish models to dissect and enhance heart regenerationR35HL150713 · NHLBI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI KENNETH D POSS · 2020 to 2026
$6.9MDUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6MRegulation of Appendage Regeneration in ZebrafishR01GM074057 · NIGMS · DUKE UNIVERSITY · PI POSS, KENNETH D · 2006 to 2017
$3.7MAdvanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation InjuryU01ES030672 · NIEHS · DUKE UNIVERSITY · PI ACHANTA, SATYANARAYANA, JORDT, SVEN-ERIC · 2019 to 2021
$2.3MThe role of gut endocrine cells in Parkinson's DiseaseR01DK109368 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2016 to 2019
$1.4MEnteroendocrine cells sense gut bacteria and activate a gut-brain pathwayK01DK125527 · NIDDK · OHIO STATE UNIVERSITY · PI YE, LIHUA · 2021 to 2025
$729kLightsheet Imaging SystemS10OD020010 · OD · DUKE UNIVERSITY · PI CAMERON, LISA A. · 2016 to 2016
$597kMining the Gut Microbial Metabolome for Immunomodulatory Molecules that Contribute to Health or DiseaseF32AT010415 · NCCIH · HARVARD MEDICAL SCHOOL · PI CASSILLY, CHELSI DANIELLE · 2020 to 2020
$52kGut Neuroendocrine Cell Signaling and ObesityI01BX002230 · VA · DURHAM VA MEDICAL CENTER · PI LIDDLE, RODGER A. · 2014 to 2022
–BLRD VA I01 BX002230NCCIH NIH HHS F32 AT010415NHLBI NIH HHS R35 HL150713NIDDK NIH HHS K01 DK125527NIDDK NIH HHS R01 DK093399NIDDK NIH HHS R01 DK109368NIDDK NIH HHS T32 DK007568NIEHS NIH HHS U01 ES030672NIGMS NIH HHS R01 GM074057NIH HHS S10 OD020010
Abstract
The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains unknown. Using in vivo real-time measurements of EEC and nervous system activity in zebrafish, we discovered that the bacteria Edwardsiella tarda activate EECs through the receptor transient receptor potential ankyrin A1 (Trpa1) and increase intestinal motility. Microbial, pharmacological, or optogenetic activation of Trpa1
Indexed as
AnimalsAnimals, Genetically ModifiedCholinergic NeuronsEdwardsiella tardaEnteric Nervous SystemEnteroendocrine CellsGastrointestinal MotilityIntestinal MucosaProto-Oncogene Proteins c-retSerotoninSignal TransductionTRPA1 Cation ChannelTryptophanZebrafishZebrafish ProteinsProto-Oncogene Proteins c-retRet protein, zebrafishSerotoninTRPA1 Cation ChannelTryptophanZebrafish Proteinsbacterial tryptophan catabolismDanio rerioenteroendocrine cellsgut-brain axis communicationgut microbesindoleindole-3-carboxaldehydeintestinal peristalsisserotonin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.