Evidence map›Paper›PMID 33352085›Full record

ReviewEmerging infectious diseases2021

Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015.

Elena Pérez-Nadales, Ana Alastruey-Izquierdo, María José Linares-Sicilia, Juan Carlos Soto-Debrán, Edson Abdala, Julio García-Rodríguez, Miguel Montejo, Patricia Muñoz, Miguel Salavert Lletí, Antonio Rezusta and 18 more

Open access · diamondAbstract readReview
In one paragraph

Review in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Medical mycology case reports · 2026
    Article
  5. Article
  6. Article
  7. Clinical Features and Outcomes of InvasiveJournal of fungi (Basel, Switzerland) · 2025
    Article
  8. The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Invasive fusariosis.Clinical microbiology reviews · 2023
    Review
  11. Article
  12. Non-Journal of fungi (Basel, Switzerland) · 2023
    Review
  13. Efficacy of Propolis Gel on Mature Biofilm Formed byJournal of fungi (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Pest categorisation ofEFSA journal. European Food Safety Authority · 2021
    Article
  16. Invasive Fusariosis in Patients with Hematologic Diseases.Journal of fungi (Basel, Switzerland) · 2021
    Review
  17. Fusariosis in Patients With Hematologic Malignancies in the Era of Antifungal Prophylaxis.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 12 institutions in 9 countries.

Elena Pérez-Nadales
Ana Alastruey-Izquierdo
María José Linares-Sicilia
Juan Carlos Soto-Debrán
Edson Abdala
Julio García-Rodríguez
Miguel Montejo
Patricia Muñoz
Miguel Salavert Lletí
Antonio Rezusta
Maite Ruiz Pérez de Pipaón
Lucrecia Yáñez
Esperanza Merino
María Isolina Campos-Herrero
José María Costa-Mateo
Jesús Fortún
Tomás García-Lozano
Carolina Garcia-Vidal
Mario Fernández-Ruiz
Ferrán Sánchez-Reus
Carmen Castro-Méndez
Inmaculada Guerrero-Lozano
Pere Soler-Palacín
José María Aguado
Luis Martínez-Martínez
Julian Torre-Cisneros
Marcio Nucci
Spanish Fusariosis Study Group
MSD K.K. (Japan) · JPGilead Sciences (United States) · USJanssen (Belgium) · BEMSD (Latvia) · LVNovartis (Switzerland) · CHRoche (Switzerland) · CHPfizer (United Kingdom) · GBAstellas Pharma (China) · CNGilead Sciences (Australia) · AUGilead Sciences (United Kingdom) · GBMSD (Switzerland) · CHPfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.

Indexed as

FusariosisFusariumNeutropeniaAntifungal AgentsHumansObservational Studies as TopicSpainAntifungal Agentsfungal infectionsfungifusariosisFusariumincidenceinvasive fusariosismortalitymycotic diseasesneutropeniaSpain

Identifiers

PMID33352085
PMCPMC7774531
OpenAlexW3116655052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.