ArticleACS sensors2021
Optical Imaging of Electrical and Mechanical Couplings between Cells.
Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Deep Learning Enhanced Label-Free Action Potential Detection Using Plasmonic-Based Electrochemical Impedance Microscopy.Analytical chemistry · 2024Article
- Microfluidic technologies for cell deformability cytometry.Smart medicine · 2022Review
- Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate.Cancers · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Intercellular communication plays a pivotal role in multicellular organisms. Studying the electrical and mechanical coupling among multiple cells has been a difficult task due to the lack of suitable techniques. In this study, we developed a label-free imaging method for monitoring the electrical-induced communications between connected cells. The method was based on monitoring subtle mechanical motions of the cells under electrical modulation of the membrane potential. We observed that connected cells responded to electrical modulation of neighboring cells with mechanical deformation of the membrane. We further investigated the mechanism of the coupling and confirmed that this mechanical response was induced by electrical signal communicated through the gap junction. Blocking the gap junction can temporally cease the mechanical signal, and this inhibition can be rescued after removing the inhibitor. This study sheds light on the mechanism of electrical coupling between neurons and provides a new method for studying intercellular communications.
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Registered trials
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