Evidence map›Paper›PMID 33351205›Full record

ArticleClinical endocrinology2021

Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over.

Rakibul M Islam, Robin J Bell, David J Handelsman, Penelope J Robinson, Rory Wolfe, Susan R Davis, ASPREE Investigator Group

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Approach to the patient: investigation of postmenopausal androgen excess.The Journal of clinical endocrinology and metabolism · 2026
    Review
  5. Article
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rakibul M IslamWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
Robin J BellWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
David J HandelsmanANZAC Research Institute, University of Sydney, Concord, NSW, Australia.ORCID 0000-0002-4200-7476
Penelope J RobinsonWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia.
Susan R DavisWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.ORCID 0000-0002-2955-0415
ASPREE Investigator Group
Monash University · AUThe University of Sydney · AU

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI WOLFE, RORY · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

objectiveSex steroid levels in women vary with increasing age from the age of 70 years (70+). Whether this reflects change within individuals with age or a survival advantage is not known. This study aimed to determine the stability of circulating sex steroids and SHBG over time in individual women aged 70+.

designA prospective cohort study.

participants400 women, aged 70+ not using any sex steroid, anti-androgen/oestrogen or glucocorticoid therapy. MAIN OUTCOME MEASUREMENTS: Sex steroid concentrations, measured by liquid chromatography-tandem mass spectrometry and sex hormone-binding globulin (SHBG) by immunoassay, in paired blood samples drawn 3 years apart and analysed together.

results400 women, median (IQR) age 78.0 (8.6) years, were included in the analysis. Mean testosterone concentrations were statistically significantly higher in follow-up samples compared with baseline. The change was modest (mean change 31 pmol/L, 95% confidence interval (CI) 2.4-59.8; p = .034), and an increase was not observed in all women. There was a statistically significant decline in mean body mass index (mean change -0.4 kg/m

conclusionsTestosterone concentrations in women aged 70+ were more likely to increase than decrease. Whether increasing testosterone concentrations in older women confer a survival advantage needs investigation.

Indexed as

Gonadal Steroid HormonesSex Hormone-Binding GlobulinAgedAged, 80 and overEstradiolEstrogensFemaleHumansLongitudinal StudiesProspective StudiesTestosteroneEstradiolEstrogensGonadal Steroid HormonesSex Hormone-Binding GlobulinTestosteronehormones older womenpostmenopauseSex steroids in women

Identifiers

PMID33351205
PMCPMC7957957
OpenAlexW3114541015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.