ArticleBlood advances2020
CD11c regulates hematopoietic stem and progenitor cells under stress.
Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia.JCI insight · 2026Article
- CD11cBiomedicines · 2026Article
- Multifaceted, unique role of CD11c in leukocyte biology.Frontiers in immunology · 2025Review
- Revealing potential signaling pathways and hub genes related to monocytes in sepsis survivors and non-survivors based on single-cell RNA-seq and bulk RNA-seq data.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Role of immune cell interactions in alcohol-associated liver diseases.Liver research (Beijing, China) · 2024Review
- Multiplex, high-throughput method to study cancer and immune cell mechanotransduction.Communications biology · 2024Article
- Integrin CD11c regulates B cell homeostasis.Frontiers in immunology · 2024Article
- The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease.Journal of pharmaceutical analysis · 2023Article
- Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice.The Journal of experimental medicine · 2023Article
- CD11c regulates neutrophil maturation.Blood advances · 2023Article
- CD11a regulates hematopoietic stem and progenitor cells.Frontiers in immunology · 2023Article
- New Insights into Hematopoietic Stem Cell Expansion to Stimulate Repopulation of the Adult Blood System for Transplantation.Life (Basel, Switzerland) · 2022Review
- Apolipoprotein E derived from CD11ciScience · 2022Article
- αDβ2 as a novel target of experimental polymicrobial sepsis.Frontiers in immunology · 2022Article
- CD11c regulates late-stage T cell development in the thymus.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
β2 integrins are well-known leukocyte adhesion molecules consisting of 4 members: CD11a-d. Their known biological functions range widely from leukocyte recruitment, phagocytosis, to immunological synapse formation, but the studies have been primarily focused on CD11a and CD11b. CD11c is 1 of the 4 members and is extremely homologous to CD11b. It has been well known as a dendritic cell marker, but the characterization of its function has been limited. We found that CD11c was expressed on the short-term hematopoietic stem cells and multipotent progenitor cells. The lack of CD11c did not affect the number of hematopoietic stem and progenitor cells (HSPCs) in healthy CD11c knockout mice. Different from other β2 integrin members, however, CD11c deficiency was associated with increased apoptosis and significant loss of HSPCs in sepsis and bone marrow transplantation. Although integrins are generally known for their overlapping and redundant roles, we showed that CD11c had a distinct role of regulating the expansion of HSPCs under stress. This study shows that CD11c, a well-known dendritic cell marker, is expressed on HSPCs and serves as their functional regulator. CD11c deficiency leads to the loss of HSPCs via apoptosis in sepsis and bone marrow transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.