Evidence map›Paper›PMID 33351065›Full record

ArticleBrain : a journal of neurology2021

Early-onset phenotype of bi-allelic GRN mutations.

Caroline Neuray, Tipu Sultan, Javeira Raza Alvi, Marcondes C Franca, Birgit Assmann, Matias Wagner, Laura Canafoglia, Silvana Franceschetti, Giacomina Rossi, Isabel Santana and 9 more

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The first report of ceroid lipofuscinosis type 11 in China: a novel mutation of GRN and updated clinical review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  2. Article
  3. Review
  4. Cells · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Caroline NeurayUCL Queen Square Institute of Neurology, University College London, London, UK.
Tipu SultanDepartment of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, Pakistan.
Javeira Raza AlviDepartment of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, Pakistan.
Marcondes C FrancaDepartment of Neurology, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil.
Birgit AssmannDepartment of Paediatrics, Medizinische Universität Heidelberg, Germany.
Matias WagnerInstitute of Neurogenomics, Helmholtz Zentrum Munich, Neuherberg, Germany.
Laura CanafogliaNeurolophysiopathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Silvana FranceschettiNeurolophysiopathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Giacomina RossiDivision of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Isabel SantanaDepartment of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Maria C MacarioDepartment of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Maria R AlmeidaCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
Mahesh KamateDivision of Pediatric Neurology, Department of Pediatrics, Kaher-University's J N Medical College, Belgaum, India.
Sumit ParikhDepartment of Mitochondrial Medicine and Neurogenetics, Cleveland Clinic, Cleveland, USA.
Houda Zghal ElloumiGeneDx, Gaithersburg, MD, USA.
David MurphyUCL Queen Square Institute of Neurology, University College London, London, UK.
Stephanie EfthymiouUCL Queen Square Institute of Neurology, University College London, London, UK.
Reza MaroofianUCL Queen Square Institute of Neurology, University College London, London, UK.
Henry HouldenUCL Queen Square Institute of Neurology, University College London, London, UK.

Funding

Medical Research Council G0601943Medical Research Council MR/S005021/1Medical Research Council MR/S01165X/1Wellcome Trust WT093205 MAWellcome Trust WT104033AIA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllelesHomozygoteMutationPhenotype

Identifiers

PMID33351065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.