Evidence map›Paper›PMID 33350983›Full record

ArticleAging2020

Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization.

Jiyong Zhang, Yuluo Rong, Chunyang Luo, Weiding Cui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 5 syntheses or guidelines pooled it, 188 citations in OpenAlex.

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  12. [Research progress of infrapatellar fat pad derived mesenchymal stem cells in treatment of osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiyong ZhangDepartment of Orthopaedic, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yuluo RongDepartment of Orthopaedic, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Chunyang LuoDepartment of Orthopaedic, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Weiding CuiDepartment of Orthopaedic, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Nanjing Medical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis is a chronic degenerative disease that can lead to restricted activity or even disability. Bone marrow mesenchymal stem cells can repair cartilage damage and treat osteoarthritis via cell therapies or in-tissue engineering. Research has shown that the paracrine mechanism is the main mode of action of mesenchymal stem cells. Exosomes are the smallest known membrane-bound nanovesicles. Exosomes are also important carriers of paracrine delivery agents and promote communication between cells. We demonstrated that bone marrow mesenchymal stem cell-derived exosomes can delay the progression of osteoarthritis. Exosomes alleviate cartilage damage, reduce osteophyte formation and synovial macrophage infiltration, inhibit M1 macrophage production and promote M2 macrophage generation. In synovial fluid, the expression levels of the proinflammatory cytokines, IL-1β, IL-6, and TNF-α were decreased and the release of the anti-inflammatory cytokine, IL-10 was increased.

Indexed as

AnimalsAnterior Cruciate LigamentCartilage, ArticularChondrocytesDisease Models, AnimalExosomesHypertrophyInjections, Intra-ArticularInterleukin-10Interleukin-1betaInterleukin-6MacrophagesMenisci, TibialMesenchymal Stem CellsMiceOsteoarthritisIL1B protein, ratIl6 protein, ratInterleukin-10Interleukin-1betaInterleukin-6Tumor Necrosis Factor-alphabone marrow mesenchymal stem cellsexosomesosteoarthritispolarizationsynovial macrophages

Identifiers

PMID33350983
PMCPMC7803581
OpenAlexW3115923592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.