Evidence map›Paper›PMID 33350583›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

Christian Agudelo, Wassim Tarraf, Benson Wu, Douglas M Wallace, Sanjay R Patel, Susan Redline, Sonya Kaur, Martha Daviglus, Phyllis C Zee, Guido Simonelli and 6 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Sleep and cognition in Hispanic/Latin American adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

Christian AgudeloDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Wassim TarrafDepartment of Healthcare Sciences and Institute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Benson WuDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Douglas M WallaceDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Sanjay R PatelCenter for Sleep and Cardiovascular Outcomes Research, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Susan RedlineDepartments of Medicine and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sonya KaurDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Phyllis C ZeeDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Guido SimonelliCenter for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur de Montreal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montréal, Canada.
Yasmin Mossavar-RahmaniDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Daniela Sotres-AlvarezDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Donglin ZengDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Linda C GalloDepartment of Psychology and South Bay Latino Research Center, San Diego State University, San Diego, California, USA.
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Alberto R RamosDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
University of Miami · USUniversity of North Carolina at Chapel Hill · USAlbert Einstein College of Medicine · USAlzheimer’s Disease Neuroimaging Initiative · USCentre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-MontréalHarvard University · USNorthwestern University · USSan Diego State University · USUniversity of California, San Diego · USUniversity of Illinois Chicago · USUniversity of Pittsburgh · USWayne State University · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)R01AG067568 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Alberto Rafael Ramos · 2021 to 2026
$13.7M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Sleep Patterns as a risk factor for disease in the Hispanic Community Health StudR01HL098297 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI PATEL, SANJAY R · 2010 to 2013
$3.1M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR)R21AG056952 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, ALBERTO RAFAEL · 2017 to 2018
$411k
Sleep Apnea Phenotypes in Latinos (SLEPT)R21HL140437 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, ALBERTO RAFAEL · 2019 to 2020
$258k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
Albert Einstein College of Medicine N01-HC65235National Heart Lung Blood Institute R01HL098297NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL098297NHLBI NIH HHS R21 HL140437NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG048642NIA NIH HHS R01AG048642NIA NIH HHS R01 AG067568NIA NIH HHS R21 AG056952NIA NIH HHS R21AG056952NIA NIH HHS RF1 AG054548NIA NIH HHS RF1AG054548NIA NIH HHS RF1 AG061022NIA NIH HHS RF1AG061022Northwestern University N01-HC65236San Diego State University N01-HC65237University of Miami N01-HC65234University of North Carolina N01-HC65233
6 · The paper itself

Abstract

introductionWe determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults.

methodsWe examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates.

resultsLonger sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change.

conclusionIn a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

Indexed as

Public HealthActigraphyCognitive DysfunctionFemaleHispanic or LatinoHumansMaleMiddle AgedNeuropsychological TestsProspective StudiesRisk FactorsSleepSurveys and QuestionnairesUnited Statesactigraphycognitive declinecohort studiesHispanic/Latinosrisk factors in epidemiologysleep

Identifiers

PMID33350583
PMCPMC8312581
OpenAlexW3116475478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.