Evidence map›Paper›PMID 33350517›Full record

ArticleJournal of veterinary internal medicine2021

In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging.

Philippa J Johnson, Andrew D Miller, Jonathan Cheetham, Elena A Demeter, Wen-Ming Luh, John P Loftus, Sarah L Stephan, Curtis W Dewey, Erica F Barry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Common Neurologic Diseases in Geriatric Dogs.Animals : an open access journal from MDPI · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Brain diffusion tensor imaging in dogs with degenerative myelopathy.Journal of veterinary internal medicine · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Philippa J JohnsonDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID https://orcid.org/0000-0002-4558-0745
Andrew D MillerDepartment of Biomedical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Jonathan CheethamDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Elena A DemeterDepartment of Biomedical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Wen-Ming LuhNational Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
John P LoftusDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID https://orcid.org/0000-0001-7181-7155
Sarah L StephanDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Curtis W DeweyDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Erica F BarryDepartment of Clinical Sciences, Cornell College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Cornell University · USNational Institutes of Health · US

Funding

Morris Animal Foundation D18CA-310
6 · The paper itself

Abstract

backgroundDegenerative myelopathy (DM) in dogs is a progressive neurodegenerative condition that causes white matter spinal cord lesions. These lesions are undetectable on standard magnetic resonance imaging (MRI), limiting diagnosis and monitoring of the disease. Spinal cord lesions cause disruption to the structural integrity of the axons causing water diffusion to become more random and less anisotropic. These changes are detectable by the technique of diffusion tensor imaging (DTI) which is highly sensitive to diffusion alterations secondary to white matter lesion development.

objectivePerform spinal DTI on cohorts of dogs with and without DM to identify if lesions caused by DM will cause a detectable alteration in spinal cord diffusivity that correlates with neurological status. ANIMALS: Thirteen dogs with DM and 13 aged-matched controls.

methodsAll animals underwent MRI with DTI of the entire spine. Diffusivity parameters fractional anisotropy (FA) and mean diffusivity (MD) were measured at each vertebral level and statistically compared between groups.

resultsDogs with DM had significant decreases in FA within the regions of the spinal cord that had high expected lesion load. Decreases in FA were most significant in dogs with severe forms of the disease and correlated with neurological grade. CONCLUSIONS AND CLINICAL IMPORTANCE: Findings suggest that FA has the potential to be a biomarker for spinal cord lesion development in DM and could play an important role in improving diagnosis and monitoring of this condition.

Indexed as

Dog DiseasesSpinal Cord DiseasesWhite MatterAnimalsAnisotropyDiffusion Tensor ImagingDogsSpinal Corddiffusion tensor imagingfractional anisotropymagnetic resonance imagingmean diffusivity

Identifiers

PMID33350517
PMCPMC7848345
OpenAlexW3116805029

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.