ArticleeLife2020
Open access · goldAbstract readCase Reports
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions.Metabolic brain disease · 2024Pooled it
- Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure.Neurotoxicology · 2026Article
- Identification and characterisation of a novel homozygous KDM5A variant associated with severe axial hypotonia, seizures, and cardiac anomalies.Journal of human genetics · 2026Article
- Mitochondrial-Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance.Molecular neurobiology · 2026Review
- Monoallelic and biallelic KDM5A variants identified in patients with autism spectrum disorder.HGG advances · 2026Article
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency.Science advances · 2026Article
- The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes.Disease models & mechanisms · 2026Article
- Individuals with reported and novel KDM5C variants present with seizures, a feature recapitulated in a Drosophila model.Human molecular genetics · 2026Article
- Review
- Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5.Epigenetics & chromatin · 2025Article
- Article
- FBXO22 deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature.American journal of human genetics · 2025Article
- Molecular and clinical aspects of histone-related disorders.Human genomics · 2025Review
- Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders.iScience · 2025Review
- Kismet/CHD7/CHD8 affects gut microbiota, mechanics, and the gut-brain axis in Drosophila melanogaster.Biophysical journal · 2025Article
- Developmental Disruption of Mef2c in Medial Ganglionic Eminence-Derived Cortical Inhibitory Interneurons Impairs Cellular and Circuit Function.Biological psychiatry · 2024Article
- Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation.The Journal of biological chemistry · 2024Review
- A Genotype/Phenotype Study ofGenes · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 13 institutions in 6 countries.
Lauretta El HayekEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-6820-9316
Islam Oguz TuncayDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States.
Nadine NijemEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States.
Jamie RussellCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Kiran KaurEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Priscilla AndertonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Amanda GerardDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Anja HeinzeInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Pia ZacherInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Hessa S AlsaifDepartment of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Aboulfazl RadCellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Islamic Republic of Iran.ORCID 0000-0001-8627-8828
Kazem HassanpourNon-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Islamic Republic of Iran.
Mohammad Reza AbbaszadeganPardis Clinical and Genetics Laboratory, Mashhad, Islamic Republic of Iran.
Camerun WashingtonGreenwood Genetic Center, Greenwood, United States.
Barbara R DuPontGreenwood Genetic Center, Greenwood, United States.
Raymond J LouieGreenwood Genetic Center, Greenwood, United States.
CAUSES StudyDepartment of Medical Genetics, University of British Columbia, British Columbia Children's and Women's Hospital Research Institute, Vancouver, Canada.
Madeline CouseDepartment of Medical Genetics, University of British Columbia, British Columbia Children's and Women's Hospital Research Institute, Vancouver, Canada.
Maha FadenDepartment of Genetics, King Saud Medical City, Riyadh, Saudi Arabia.
R Curtis RogersGreenwood Genetic Center, Greenwood, United States.
Rami Abou JamraInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Ellen R EliasDepartment of Pediatrics and Genetics, University of Colorado School of Medicine, Aurora, United States.
Reza MaroofianDepartment of Neuromuscular Diseases, University College London, Queen Square Institute of Neurology, London, United Kingdom.
Henry HouldenDepartment of Neuromuscular Diseases, University College London, Queen Square Institute of Neurology, London, United Kingdom.
Anna LehmanDepartment of Medical Genetics, University of British Columbia, British Columbia Children's and Women's Hospital Research Institute, Vancouver, Canada.
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Maria H ChahrourEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-3174-1480
Southwestern Medical Center · USGreenwood Genetic Center · USUniversity of British Columbia · CAPediatrics and Genetics · USSabzevar University of Medical Sciences · IRBaylor College of Medicine · USEpilepsiezentrum Kleinwachau Gemeinnützige · DEKing Faisal Specialist Hospital & Research Centre · SAKing Saud Medical City · SALeipzig University · DEMashhad University of Medical Sciences · IRNational Hospital for Neurology and Neurosurgery · GBThe University of Texas Southwestern Medical Center · US
Funding
Welch Foundation I-1946-20180324
Abstract
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with high phenotypic and genetic heterogeneity, complicating the discovery of causative genes. Through a forward genetics approach selecting for defective vocalization in mice, we identified
Indexed as
AdolescentAnimalsAutism Spectrum DisorderChild, PreschoolFemaleGenetic Predisposition to DiseaseGenetic TechniquesHumansMaleMiceMice, KnockoutMutationRetinoblastoma-Binding Protein 2KDM5A protein, humanKDM5A protein, mouseRetinoblastoma-Binding Protein 2autism spectrum disorderchromatin regulatorforward geneticsgeneticsgenomicshistone demethylasehumanmedicinemousevocalization
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.