Evidence map›Paper›PMID 33350380›Full record

ArticleeLife2020

Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds.

Minhui Ouyang, Qinmu Peng, Tina Jeon, Roy Heyne, Lina Chalak, Hao Huang

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minhui OuyangRadiology Research, Children's Hospital of Philadelphia, Philadelphia, United States.
Qinmu PengRadiology Research, Children's Hospital of Philadelphia, Philadelphia, United States.
Tina JeonRadiology Research, Children's Hospital of Philadelphia, Philadelphia, United States.
Roy HeyneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Lina ChalakDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
Hao HuangRadiology Research, Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0002-9103-4382

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Michael Byrne Robinson · 2021 to 2026
$9.2M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 2016 to 2020
$6.3M
Structural Development of Human Fetal BrainR01MH092535 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, HAO · 2011 to 2020
$4.6M
NICHD NIH HHS P50 HD105354NICHD NIH HHS U54 HD086984NIMH NIH HHS R01 MH092535
6 · The paper itself

Abstract

Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0-2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development and identify biomarkers for early detection and tailored intervention in atypical development. Here we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at the age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as a potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.

Indexed as

Cerebral CortexChild DevelopmentChild, PreschoolDiffusion Magnetic Resonance ImagingFemaleHumansImage Interpretation, Computer-AssistedInfant, NewbornMaleNeurodevelopmental DisordersNeuroimagingSupport Vector Machinebehaviorbrain developmentcortical microstructurediffusion MRIhumaninfantsneuroscienceprediction

Identifiers

PMID33350380
PMCPMC7755384

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.