Evidence map›Paper›PMID 33350306›Full record

ArticleACS chemical biology2021

Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in

David R Jackson, Chelsi D Cassilly, Damian R Plichta, Hera Vlamakis, Hualan Liu, Stephen B Melville, Ramnik J Xavier, Jon Clardy

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Identification ofApplied and environmental microbiology · 2026
    Article
  5. Microorganisms · 2026
    Article
  6. Origin of eukaryotic plasmalogen biosynthesis by horizontal gene transfer from myxobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Journal of the American Chemical Society · 2025
    Article
  13. Article
  14. Spontaneous Generation of an Endogenous RORγt Agonist.Journal of the American Chemical Society · 2025
    Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Plasmalogen, a glycerophospholipid crucial forApplied and environmental microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David R JacksonDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.ORCID 0000-0002-8676-9464
Chelsi D CassillyDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.
Damian R PlichtaBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Hualan LiuDepartment of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, United States.
Stephen B MelvilleDepartment of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, United States.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.ORCID 0000-0003-0213-8356
Broad Institute · USHarvard University · USVirginia Tech · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, XAVIER, RAMNIK J · 2017 to 2021
$3.3M
Discovery of Small Molecule Immunomodulators from Disease-Associated Microbiome MembersF32GM122233 · NIGMS · HARVARD MEDICAL SCHOOL · PI JACKSON, DAVID RICHARD · 2017 to 2018
$118k
Mining the Gut Microbial Metabolome for Immunomodulatory Molecules that Contribute to Health or DiseaseF32AT010415 · NCCIH · HARVARD MEDICAL SCHOOL · PI CASSILLY, CHELSI DANIELLE · 2020 to 2020
$52k
NCCIH NIH HHS F32 AT010415NCCIH NIH HHS R01 AT009708NIDDK NIH HHS P30 DK043351NIGMS NIH HHS F32 GM122233
6 · The paper itself

Abstract

Plasmalogens are vinyl ether-containing lipids produced by mammals and bacteria. The aerobic biosynthetic pathway in eukaryotes and bacteria is known, but the anaerobic pathway has remained a mystery. Here, we describe a two-gene operon (plasmalogen synthase,

Indexed as

Genes, BacterialOperonClostridium perfringensEnterococcus faecalisEscherichia coliOpen Reading FramesOxidation-ReductionPlasmalogensPlasmalogens

Identifiers

PMID33350306
PMCPMC7812594
OpenAlexW3114267421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.