Evidence map›Paper›PMID 33350297›Full record

ArticleTurkish journal of medical sciences2021

Inflammatory complications of vocal fold injection with hyaluronic acid: a multiinstitutional study

Necati Enver, Elad Azizli, Sevtap Akbulut, Emel Çadallı Tatar, Muhammed Kürşad Yelken, Kayhan Öztürk, Hakan Coşkun, Ahmet Hakan Birkent, Zahide Çiler Büyükatalay, Ozan Bağış Özgürsoy and 1 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Turkish journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Injection laryngoplasty with hyaluronic acid for glottal insufficiency in unilateral vocal fold paralysis: a systematic review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Safety profile of office-based Hyadex® injection laryngoplasty: a 146-procedure single-center experience.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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  4. Review
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  6. Exploring the anti-inflammatory potential of topical hyaluronic acid for vocal fold injury in a rat model.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 3 countries.

Necati EnverDepartment of Otolaryngology, Pendik Training and Research Hospital, Marmara University, İstanbul, TurkeyORCID 0000-0002-3161-8810
Elad AzizliDepartment of Otolaryngology, Private Practise, İstanbul, TurkeyORCID 0000-0002-6494-8664
Sevtap AkbulutDepartment of Otolaryngology, Faculty of Medicine, Yeditepe University, İstanbul, TurkeyORCID 0000-0003-3334-657X
Emel Çadallı TatarDepartment of Otolaryngology, Dışkapı Yıldırım Beyazıt Research and Training Hospital, University of Health Sciences, Ankara,TurkeyORCID 0000-0002-8923-1408
Muhammed Kürşad YelkenDepartment of Otolaryngology, Faculty of Medicine, Maltepe University, İstanbul, TurkeyORCID 0000-0001-8133-2717
Kayhan ÖztürkDepartment of Otorhinolaryngology, Medicana Konya Hospital, Faculty of Medicine, KTO Karatay University, Konya, TurkeyORCID 0000-0001-8141-0965
Hakan CoşkunDepartment of Otolaryngology, Faculty of Medicine, Bursa Uludağ University, TurkeyORCID 0000-0002-0881-1444
Ahmet Hakan BirkentDepartment of Otorhinolaryngology, Nişantaşı University, İstanbul, TurkeyORCID 0000-0001-9545-6518
Zahide Çiler BüyükatalayDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Ankara University Ankara, TurkeyORCID 0000-0002-0992-0079
Ozan Bağış ÖzgürsoyDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Ankara University Ankara, TurkeyORCID 0000-0002-2300-9070
Haldun OğuzDepartment of Otolaryngology, Fonomer, Ankara, TurkeyORCID 0000-0003-2106-4735
Ankara University · TRBursa Uludağ Üni̇versi̇tesi̇ · TRIstanbul Technical University · TRKTO Karatay University · TRMaltepe University · TRMarmara University · TRMinistry of Health · TRSmall and Medium Enterprises Development Organization · TRTurkish Society of Hematology · TRYeditepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: This study aimed to assess the inflammatory adverse reactions of vocal fold injection laryngoplasty with hyaluronic acid. Materials and methods: This study was a retrospective chart review of patients who underwent vocal fold injection augmentation with HA injection from January 2005 to September 2016 in nine different institutions. Demographic data, indication for injection, injection techniques, types of injection material, settings of procedure, and complications were reviewed. The types of complication, onset time, and management of complications were also noted. Results: In all, 467 patients were identified. The majority of patients had been injected under general anesthesia (n = 382, 84.7%). For injection material, two different types of hyaluronic acid were used: hyaluronic acid alone or hyaluronic acid with dextranomer. Complications occurred in nine patients (1.9%). The majority of complications were inflammatory reactions (n = 7, 1.47%). Main symptoms were dysphonia and/or dyspnea with an onset of 0 h to 3 weeks after the hyaluronic acid injection. Three patients were hospitalized, one of which was also intubated and observed in the intensive care unit for 24 h. Systemic steroids and antibiotics were the main medical treatment in the majority of cases. There was no statistical difference in complication rates between patients who received hyaluronic acid and those who received hyaluronic acid with dextranomer (P = 0.220). Conclusion: Hyaluronic acid can be considered as a safe substance for the injection of vocal folds with a low risk of inflammatory reaction.

Indexed as

LaryngoplastyAdjuvants, ImmunologicAdultAgedFemaleHumansHyaluronic AcidMaleMiddle AgedMinimally Invasive Surgical ProceduresRetrospective StudiesVocal Cord ParalysisVocal CordsYoung AdultAdjuvants, ImmunologicHyaluronic Acidhyaluronic acidhyaluronic acid with dextranomerinflammatory reactionsulcus vocalisVocal fold injectionvocal fold paralysis

Identifiers

PMID33350297
PMCPMC8203174
OpenAlexW3114497692

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.