Evidence map›Paper›PMID 33350091›Full record

ReviewJournal of cellular and molecular medicine2021

Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects.

Ying Tang, Jinghui Bao, Jiahui Hu, Leiling Liu, Dan-Yan Xu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Formation of Circular RNAs.Advances in experimental medicine and biology · 2025
    Review
  9. circRNAs in Endometrial Cancer-A Promising Biomarker: State of the Art.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ying TangDepartment of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Jinghui BaoDepartment of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Jiahui HuDepartment of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Leiling LiuDepartment of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Dan-Yan XuDepartment of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-2113-0800
Central South University · CN

Funding

National Natural Science Foundation of China 81672264National Natural Science Foundation of China 81871858
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non-coding RNAs, which exist widely in human tissues including the heart. Increasing evidence has shown that cardiac circRNAs play crucial regulatory roles in cardiovascular diseases (CVDs). In this review, we aimed to provide a systemic understanding of circRNAs with a special emphasis on the cardiovascular system. We have summarized the current research on the classification, biogenesis and properties of circRNAs as well as their participation in the pathogenesis of CVDs. CircRNAs are conserved, stable and have specific spatiotemporal expression; thus, they have been accepted as a potential diagnostic marker or an incremental prognostic biomarker for CVDs.

Indexed as

BiomarkersDisease SusceptibilityGene Expression RegulationRNA, CircularCardiovascular DiseasesGene Regulatory NetworksHumansMicroRNAsMolecular Diagnostic TechniquesPhenotypePrognosisRNA InterferenceRNA, MessengerTranscription, GeneticBiomarkersMicroRNAsRNA, CircularRNA, Messengerbiogenesiscardiovascular diseasecircRNAmiRNARNA-binding protein

Identifiers

PMID33350091
PMCPMC7882961
OpenAlexW3117000411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.