Evidence map›Paper›PMID 33349928›Full record

ArticleEuropean journal of immunology2021

Autophagy regulates long-term cross-presentation by murine dendritic cells.

Nataschja I Ho, Marcel G M Camps, Martijn Verdoes, Christian Münz, Ferry Ossendorp

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nataschja I HoDepartment of Immunology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-4071-9370
Marcel G M CampsDepartment of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Martijn VerdoesDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Ferry OssendorpDepartment of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLRadboud University Nijmegen · NLUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy has been reported to be involved in supporting antigen cross-presentation by dendritic cells (DCs). We have shown that DCs have the ability to store antigen for a prolonged time in endolysosomal compartments and thereby sustain MHCI antigen cross-presentation to CD8

Indexed as

AnimalsAntigen PresentationAutophagosomesAutophagyAutophagy-Related Protein 5CD8-Positive T-LymphocytesCell LineCross-PrimingDendritic CellsHistocompatibility Antigens Class IMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalMicrotubule-Associated ProteinsWortmanninAutophagy-Related Protein 5Histocompatibility Antigens Class IMap1lc3b protein, mouseMicrotubule-Associated ProteinsWortmanninautophagycross-presentationDCLC3MHCI

Identifiers

PMID33349928
PMCPMC8248248
OpenAlexW3116231626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.