Evidence map›Paper›PMID 33349923›Full record

ArticleBiometrics2022

Causal inference in high dimensions: A marriage between Bayesian modeling and good frequentist properties.

Joseph Antonelli, Georgia Papadogeorgou, Francesca Dominici

Abstract read
In one paragraph

Article in Biometrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  8. A reference-free R-learner for treatment recommendation.Statistical methods in medical research · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph AntonelliDepartment of Statistics, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-7464-5766
Georgia PapadogeorgouDepartment of Statistics, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-1982-2245
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-9382-0141

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Statistical Methods for the Spatio-Temporal Assessment of Social Disparities in CancerP01CA134294 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LIN, XIHONG · 2008 to 2017
$6.8M
Project 3: Cumulative Risk and Geospatial Health Disparities Related to Chemical and Non-Chemical Stressor ExposuresP50MD010428 · NIMHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI LADEN, FRANCINE, LEVY, JONATHAN I · 2015 to 2020
$4.0M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
Machine Learning for Health Outcomes and Quality of Care in Low-Income PopulationsDP2MD012722 · NIMHD · STANFORD UNIVERSITY · PI ROSE, SHERRI · 2017 to 2017
$2.5M
Cardiovascular Health and Air Pollution: A National StudyR01ES024332 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2015 to 2018
$2.5M
Bayesian Methods for Comparative Effectiveness Research with Observational DataR01GM111339 · NIGMS · HARVARD MEDICAL SCHOOL · PI NORMAND, SHARON-LISE TERESA · 2015 to 2018
$2.5M
Causal Inference with Interference for Evaluating Air Quality PoliciesR01ES026217 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI ZIGLER, CORWIN MATTHEW · 2016 to 2021
$2.2M
Training Program in Comparative Effectiveness Research for Suicide PreventionT32MH125815 · NIMH · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN, MATTHEW K NOCK · 2022 to 2026
$1.2M
CRCNS: Geometry-based Brain Connectome AnalysisR01MH118927 · NIMH · DUKE UNIVERSITY · PI DUNSON, DAVID BRIAN, ZHANG, ZHENGWU · 2018 to 2020
$945k
NCI NIH HHS P01 CA134294NCI NIH HHS R35 CA197449NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES024332NIEHS NIH HHS R01 ES026217NIEHS NIH HHS R01 ES028033NIEHS NIH HHS T32 ES007142NIGMS NIH HHS R01 GM111339NIMHD NIH HHS DP2 MD012722NIMHD NIH HHS P50 MD010428NIMH NIH HHS R01 MH118927NIMH NIH HHS T32 MH125815
6 · The paper itself

Abstract

We introduce a framework for estimating causal effects of binary and continuous treatments in high dimensions. We show how posterior distributions of treatment and outcome models can be used together with doubly robust estimators. We propose an approach to uncertainty quantification for the doubly robust estimator, which utilizes posterior distributions of model parameters and (1) results in good frequentist properties in small samples, (2) is based on a single run of a Markov chain Monte Carlo (MCMC) algorithm, and (3) improves over frequentist measures of uncertainty which rely on asymptotic properties. We consider a flexible framework for modeling the treatment and outcome processes within the Bayesian paradigm that reduces model dependence, accommodates nonlinearity, and achieves dimension reduction of the covariate space. We illustrate the ability of the proposed approach to flexibly estimate causal effects in high dimensions and appropriately quantify uncertainty. We show that our proposed variance estimation strategy is consistent when both models are correctly specified, and we see empirically that it performs well in finite samples and under model misspecification. Finally, we estimate the effect of continuous environmental exposures on cholesterol and triglyceride levels.

Indexed as

Models, StatisticalBayes TheoremCausalityComputer SimulationMonte Carlo MethodBayesian modelingcausal inferencedoubly robust estimationenvironmental exposureshigh-dimensional datamodel selectionvariable selection

Identifiers

PMID33349923
PMCPMC8209114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.