Evidence map›Paper›PMID 33349859›Full record

ArticleInternational journal of epidemiology2021

A demographic scaling model for estimating the total number of COVID-19 infections.

Christina Bohk-Ewald, Christian Dudel, Mikko Myrskylä

Abstract read
In one paragraph

Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. COVID-19 trends across borders: Identifying correlations among countries.The Journal of international medical research · 2024
    Article
  3. Article
  4. Article
  5. Nanomaterials-based sensors for the detection of COVID-19: A review.Bioengineering & translational medicine · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. SARS-CoV-2 infections in 165 countries over time.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Review
  19. No clear association emerges between intergenerational relationships and COVID-19 fatality rates from macro-level analyses.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christina Bohk-EwaldMax Planck Institute for Demographic Research, Rostock, Germany.
Christian DudelMax Planck Institute for Demographic Research, Rostock, Germany.
Mikko MyrskyläMax Planck Institute for Demographic Research, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding how widely COVID-19 has spread is critical information for monitoring the pandemic. The actual number of infections potentially exceeds the number of confirmed cases. DEVELOPMENT: We develop a demographic scaling model to estimate COVID-19 infections, based on minimal data requirements: COVID-19-related deaths, infection fatality rates (IFRs), and life tables. As many countries lack IFR estimates, we scale them from a reference country based on remaining lifetime to better match the context in a target population with respect to age structure, health conditions and medical services. We introduce formulas to account for bias in input data and provide a heuristic to assess whether local seroprevalence estimates are representative for the total population. APPLICATION: Across 10 countries with most reported COVID-19 deaths as of 23 July 2020, the number of infections is estimated to be three [95% prediction interval: 2-8] times the number of confirmed cases. Cross-country variation is high. The estimated number of infections is 5.3 million for the USA, 1.8 million for the UK, 1.4 million for France, and 0.4 million for Peru, or more than one, six, seven and more than one times the number of confirmed cases, respectively. Our central prevalence estimates for entire countries are markedly lower than most others based on local seroprevalence studies.

conclusionsThe national infection estimates indicate that the pandemic is far more widespread than the numbers of confirmed cases suggest. Some local seroprevalence estimates largely deviate from their corresponding national mean and are unlikely to be representative for the total population.

Indexed as

SARS-CoV-2AdolescentAdultCOVID-19HumansModels, TheoreticalPandemicsPrevalenceSeroepidemiologic StudiesYoung Adultbias assessmentCOVID-19indirect estimationinfectionlocal seroprevalence studiesprevalence

Identifiers

PMID33349859
PMCPMC7799106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.