Evidence map›Paper›PMID 33349708›Full record

ArticleNature immunology2021

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.

Johnathan Canton, Hanna Blees, Conor M Henry, Michael D Buck, Oliver Schulz, Neil C Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart and 8 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.

  1. Pooled it
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  13. WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Control of antigen presentation on MHC-I by a bacterial secretion system.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Johnathan Canton *Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Hanna Blees *Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Conor M Henry *Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Michael D BuckImmunobiology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0002-9611-1199
Oliver SchulzImmunobiology Laboratory, The Francis Crick Institute, London, UK.
Neil C RogersImmunobiology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0001-8977-7585
Eleanor ChildsImmunobiology Laboratory, The Francis Crick Institute, London, UK.
Santiago ZelenayCancer Inflammation and Immunity Group, CRUK Manchester Institute, The University of Manchester, Alderley Park, UK.
Hefin RhysFlow Cytometry STP, The Francis Crick Institute, London, UK.
Marie-Charlotte DomartElectron Microscopy STP, The Francis Crick Institute, London, UK.
Lucy CollinsonElectron Microscopy STP, The Francis Crick Institute, London, UK.ORCID 0000-0003-0260-613X
Andres AlloattiCentre de Recherche, INSERM U932, Institut Curie, Paris, France.
Cara J EllisonDivision of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, UK.
Sebastian AmigorenaCentre de Recherche, INSERM U932, Institut Curie, Paris, France.
Venizelos PapayannopoulosAntimicrobial Defence Laboratory, The Francis Crick Institute, London, UK.
David C ThomasImmunity and Inflammation, 9NC, Imperial College, London, UK.
Felix RandowDivision of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-0694-5315
Caetano Reis e SousaImmunobiology Laboratory, The Francis Crick Institute, London, UK. caetano@crick.ac.uk.ORCID 0000-0001-7392-2119
The Francis Crick Institute · GBInserm · FRMRC Laboratory of Molecular Biology · GBImperial College London · GBUniversity of Manchester · GB

Funding

Cancer Research UK 22255Cancer Research UK FC001136European Research Council 268670Medical Research Council MC_U105170648Wellcome Trust 104752Wellcome Trust 106973
6 · The paper itself

Abstract

Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8

Indexed as

Antigen PresentationCross-PrimingAnimalsCell DeathCoculture TechniquesDendritic CellsHEK293 CellsHistocompatibility Antigens Class IHumansLectins, C-TypeLigandsMiceNADPH OxidasesPhagosomesPhosphorylationRAW 264.7 CellsCLEC9a protein, humanClec9a protein, mouseHistocompatibility Antigens Class ILectins, C-TypeLigandsNADPH OxidasesReactive Oxygen SpeciesReceptors, ImmunologicReceptors, MitogenSyk KinaseSYK protein, humanSyk protein, mouse

Identifiers

PMID33349708
PMCPMC7116638
OpenAlexW3113464424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.