ArticleNature chemical biology2021
Living materials fabricated via gradient mineralization of light-inducible biofilms.
Article in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 133 citations in OpenAlex.
- Engineered E. coli swarming for binary and analog input recording.Molecular systems biology · 2026Article
- Living co-culture fabrication for biologically crosslinked mycelium-cellulose hydrogels and films.Nature communications · 2026Article
- Gene Editing-Driven Engineering of Microbial Systems and Metabolites for Precision Medicine and Sustainable Environmental Remediation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Polymer chemistry at the living-material interface.Chemical science · 2026Review
- Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease.Nature biotechnology · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Solving Challenges in Microalgae-Based Living Materials.ACS synthetic biology · 2025Article
- Bio-Informed Porous Mineral-Based Composites.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Engineered nascent living human tissues with unit programmability.Nature materials · 2025Article
- Mechanically Tunable, Compostable, Healable and Scalable Engineered Living Materials.Nature communications · 2024Article
- Induction of bacterial expression at the mRNA level by light.Nucleic acids research · 2024Article
- Active interface bulging inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Accelerating the design of pili-enabled living materials using an integrative technological workflow.Nature chemical biology · 2024Article
- Materials-driven strategies in bacterial engineering.MRS communications · 2024Review
- Cytoprotective Metal-Phenolic Network Sporulation to Modulate Microalgal Mobility and Division.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Living Material with Temperature-Dependent Light Absorption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Remote control of mechanochemical reactions under physiological conditions using biocompatible focused ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living organisms have evolved sophisticated cell-mediated biomineralization mechanisms to build structurally ordered, environmentally adaptive composite materials. Despite advances in biomimetic mineralization research, it remains difficult to produce mineralized composites that integrate the structural features and 'living' attributes of their natural counterparts. Here, inspired by natural graded materials, we developed living patterned and gradient composites by coupling light-inducible bacterial biofilm formation with biomimetic hydroxyapatite (HA) mineralization. We showed that both the location and the degree of mineralization could be regulated by tailoring functional biofilm growth with spatial and biomass density control. The cells in the composites remained viable and could sense and respond to environmental signals. Additionally, the composites exhibited a maximum 15-fold increase in Young's modulus after mineralization and could be applied to repair damage in a spatially controlled manner. Beyond insights into the mechanism of formation of natural graded composites, our study provides a viable means of fabricating living composites with dynamic responsiveness and environmental adaptability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.