ArticleNature chemistry2021
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity.
Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
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Who cites it
31 citing papers in PubMed.
- Forces in mechanically interlocked materials.Chemical Society reviews · 2026Review
- Force Reveals Hidden Conformations and Dissociation Pathways in Individual π-Interacting Dimers.Angewandte Chemie (International ed. in English) · 2026Article
- Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Modeling Targeted Mechanochemistry in Polymeric Solids.Chemical reviews · 2026Review
- Mechanochemical disassembly pathways of self-assembled polymer-decorated PdNature communications · 2026Article
- Quantitative stress and damage mapping in multiple network elastomers using a single mechanophore.Nature communications · 2025Article
- High-Throughput Discovery of Ferrocene Mechanophores with Enhanced Reactivity and Network Toughening.ACS central science · 2025Article
- Hinge-Like Mechanochromic Mechanophores Based on [2.2]Paracyclophane.Angewandte Chemie (International ed. in English) · 2025Article
- Ferrocene-Functionalized Black Phosphorus Nanoplatform Enables Targeted and Prolonged MRI Visualization of Atherosclerotic Plaques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- From 18- to 20-electron ferrocene derivatives via ligand coordination.Nature communications · 2025Article
- Structure-property relationships for the force-triggered disrotatory ring-opening of cyclobutene.Chemical science · 2025Article
- Strain-Induced Photochemical Opening of Ferrocene[6]cycloparaphenylene: Uncaging of FeJournal of the American Chemical Society · 2025Article
- Advancing the Mechanosensitivity of Atropisomeric Diarylethene Mechanophores through a Lever-Arm Effect.Journal of the American Chemical Society · 2025Article
- Review
- Mechanochemical Approaches to Fundamental Studies in Soft-Matter Physics.Angewandte Chemie (International ed. in English) · 2024Review
- Side-Chain Type Ferrocene Macrocycles.Precision chemistry · 2024Article
- Azobenzene as a photoswitchable mechanophore.Nature chemistry · 2024Article
- Incorporation of a self-immolative spacer enables mechanically triggered dual payload release.Chemical science · 2024Article
- Coumarin Dimer Is an Effective Photomechanochemical AND Gate for Small-Molecule Release.Journal of the American Chemical Society · 2023Article
- Furan Release via Force-Promoted Retro-[4+2][3+2] Cycloaddition.Journal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanophores can be used to produce strain-dependent covalent chemical responses in polymeric materials, including stress strengthening, stress sensing and network remodelling. In general, it is desirable for mechanophores to be inert in the absence of force but highly reactive under applied tension. Metallocenes possess potentially useful combinations of force-free stability and force-coupled reactivity, but the mechanistic basis of this reactivity remains largely unexplored. Here, we have used single-molecule force spectroscopy to show that the mechanical reactivities of a series of ferrocenophanes are not correlated with ring strain in the reactants, but with the extent of rotational alignment of their two cyclopentadienyl ligands. Distal attachments can be used to restrict the mechanism of ferrocene dissociation to proceed through ligand 'peeling', as opposed to the more conventional 'shearing' mechanism of the parent ferrocene, leading the dissociation rate constant to increase by several orders of magnitude at forces of ~1 nN. It also leads to improved macroscopic, multi-responsive behaviour, including mechanochromism and force-induced cross-linking in ferrocenophane-containing polymers.
Identifiers
33349695What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.