ArticleScientific reports2020
Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Article
- The Switchmaze: an open-design device for measuring motivation and drive switching in mice.Peer community journal · 2024Article
- Investigating gene-environment interaction on attention in a double-hit model for Autism Spectrum Disorder.PloS one · 2024Article
- Cognitive training of mice attenuates age-related decline in associative learning and behavioral flexibility.Frontiers in behavioral neuroscience · 2024Article
- Dissection of neuronal circuits underlying sustained attention with the five-choice serial reaction time task.Neuroscience and biobehavioral reviews · 2023Review
- Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation.Cell reports methods · 2022Article
- Probing the Skin-Brain Axis: New Vistas Using Mouse Models.International journal of molecular sciences · 2022Review
- Designing animal-friendly behavioral tests for neuroscience research: The importance of an ethological approach.Frontiers in behavioral neuroscience · 2022Article
- Dissociating motor impairment from five-choice serial reaction time task performance in a mouse model of Angelman syndrome.Frontiers in behavioral neuroscience · 2022Article
- Training protocol for probabilistic Pavlovian conditioning in mice using an open-source head-fixed setup.STAR protocols · 2021Article
- Return of the Righting Reflex Does Not Portend Recovery of Cognitive Function in Anesthetized Rats.Frontiers in systems neuroscience · 2021Article
- The Role of Mitochondria in Optic Atrophy With Autosomal Inheritance.Frontiers in neuroscience · 2021Review
- In vivo localization of chronically implanted electrodes and optic fibers in mice.Nature communications · 2020Article
- Localizing Microemboli within the Rodent Brain through Block-Face Imaging and Atlas Registration.eNeuroArticle
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Experiments aiming to understand sensory-motor systems, cognition and behavior necessitate training animals to perform complex tasks. Traditional training protocols require lab personnel to move the animals between home cages and training chambers, to start and end training sessions, and in some cases, to hand-control each training trial. Human labor not only limits the amount of training per day, but also introduces several sources of variability and may increase animal stress. Here we present an automated training system for the 5-choice serial reaction time task (5CSRTT), a classic rodent task often used to test sensory detection, sustained attention and impulsivity. We found that full automation without human intervention allowed rapid, cost-efficient training, and decreased stress as measured by corticosterone levels. Training breaks introduced only a transient drop in performance, and mice readily generalized across training systems when transferred from automated to manual protocols. We further validated our automated training system with wireless optogenetics and pharmacology experiments, expanding the breadth of experimental needs our system may fulfill. Our automated 5CSRTT system can serve as a prototype for fully automated behavioral training, with methods and principles transferrable to a range of rodent tasks.
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