ArticleNature microbiology2021
Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa.
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- One Health approach probes zoonotic non-typhoidal Salmonella infections in China: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trial.EBioMedicine · 2025Trial
- The Manipulation of Host Cells byInternational journal of molecular sciences · 2026Review
- Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella.Nature communications · 2026Article
- Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India.PLoS neglected tropical diseases · 2026Article
- Public health data collected by PulseNet support a role forMicrobiology spectrum · 2026Article
- Provision of preferred nutrients to macrophages promotes Salmonella intracellular replication without relying on Type III secretion systems.PLoS pathogens · 2026Article
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- Exploring bet-hedging inmSystems · 2026Article
- One Health genomics reveals niche-specific lineage replacement inNational science review · 2026Article
- Investigation of a prolonged nursery outbreak ofEpidemiology and infection · 2026Article
- Review
- Host adaptation inApplied and environmental microbiology · 2026Review
- Distinct genomic trajectory among invasive Salmonella Typhimurium ST313 infections.Nature communications · 2026Article
- Integrated analysis of MALDI-TOF MS and whole-genome sequencing for subtypingFrontiers in microbiology · 2026Article
- Infection strategies ofGut microbes reports · 2026Review
- Genomic characterization of Salmonella enterica isolates causing typhoid among Ghanaian patients.PloS one · 2026Article
- Plasmid-driven clonal expansion of multidrug-resistant monophasicEmerging microbes & infections · 2025Article
- Comparative genomics ofVirulence · 2025Article
- Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi.Nature communications · 2025Article
37 more citing papers are in PubMed but not listed here.
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31 authors at 5 institutions in 3 countries.
Funding
Abstract
Bloodstream infections caused by nontyphoidal Salmonella are a major public health concern in Africa, causing ~49,600 deaths every year. The most common Salmonella enterica pathovariant associated with invasive nontyphoidal Salmonella disease is Salmonella Typhimurium sequence type (ST)313. It has been proposed that antimicrobial resistance and genome degradation has contributed to the success of ST313 lineages in Africa, but the evolutionary trajectory of such changes was unclear. Here, to define the evolutionary dynamics of ST313, we sub-sampled from two comprehensive collections of Salmonella isolates from African patients with bloodstream infections, spanning 1966 to 2018. The resulting 680 genome sequences led to the discovery of a pan-susceptible ST313 lineage (ST313 L3), which emerged in Malawi in 2016 and is closely related to ST313 variants that cause gastrointestinal disease in the United Kingdom and Brazil. Genomic analysis revealed degradation events in important virulence genes in ST313 L3, which had not occurred in other ST313 lineages. Despite arising only recently in the clinic, ST313 L3 is a phylogenetic intermediate between ST313 L1 and L2, with a characteristic accessory genome. Our in-depth genotypic and phenotypic characterization identifies the crucial loss-of-function genetic events that occurred during the stepwise evolution of invasive S. Typhimurium across Africa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.