Evidence map›Paper›PMID 33349590›Full record

ArticleEBioMedicine2021

Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.

Harriët Schellekens, Cristina Torres-Fuentes, Marcel van de Wouw, Caitriona M Long-Smith, Avery Mitchell, Conall Strain, Kirsten Berding, Thomaz F S Bastiaanssen, Kieran Rea, Anna V Golubeva and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Effects ofNutrients · 2024
    Trial
  3. Trial
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Bioscience of microbiota, food and health · 2026
    Article
  12. Article
  13. Virulence · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Harriët SchellekensAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address: H.Schellekens@ucc.ie.
Cristina Torres-FuentesAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Marcel van de WouwAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Caitriona M Long-SmithAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Avery MitchellTeagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Conall StrainTeagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Kirsten BerdingAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Thomaz F S BastiaanssenAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Kieran ReaAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Anna V GolubevaAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Silvia ArboleyaAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Mathieu VerpaalenAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Matteo M PuscedduAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Amy MurphyAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Fiona FouhyAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Kiera MurphyAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Paul RossAPC Microbiome Ireland, University College Cork, Cork, Ireland; College of Science Engineering & Food Science, University College Cork, Cork, Ireland.
Bernard L RoyCremo SA, Villars-sur-Glâne, Fribourg, Switzerland.
Catherine StantonAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland; Dept of Psychiatry and Behavioural Neuroscience, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
University College Cork · IETeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes.

methodsB. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention.

findingsB. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]).

interpretationThis study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity.

fundingThis research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.

Indexed as

Disease ResistanceHost Microbial InteractionsAdiposityAdrenal Cortex HormonesAnimalsBifidobacterium longumBiomarkersBody WeightDietary SupplementsDiet, High-FatDisease Models, AnimalEnergy MetabolismGlucoseLeptinMaleMiceAdrenal Cortex HormonesBiomarkersGlucoseLeptinNeuropeptidesBifidobacterium longumCortisolFasting blood glucoseGhrelinGut microbiotaObesityProbioticTranslational

Identifiers

PMID33349590
PMCPMC7838052
OpenAlexW3110994100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.