Evidence map›Paper›PMID 33349583›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2021

The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network.

Kelsie Pearson, Nicole Mayer-Hamblett, Christopher H Goss, George Z Retsch-Bogart, Jill M VanDalfsen, Patricia Burks, Daniel Rosenbluth, John Paul Clancy, Amy Hoffman, David P Nichols

Abstract read
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Breathe (Sheffield, England) · 2026
    Review
  2. Article
  3. The Impact of COVID-19 in Cystic Fibrosis.Archivos de bronconeumologia · 2022
    Article
  4. Review
  5. From the Editor's Desk.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Article
  6. A year in review: Real world evidence, functional monitoring and emerging therapeutics in 2021.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Review
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelsie PearsonCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States. Electronic address: kelsie.pearson@seattlechildrens.org.
Nicole Mayer-HamblettCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States; Department of Pediatrics, University of Washington, Seattle, WA, United States; Department of Biostatistics, University of Washington, Seattle, WA, United States.
Christopher H GossCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States; Department of Medicine, University of Washington, Seattle, WA, United States.
George Z Retsch-BogartDivision of Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, United States.
Jill M VanDalfsenCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States.
Patricia BurksCystic Fibrosis Foundation, Bethesda, MD, United States.
Daniel RosenbluthDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri, United States.
John Paul ClancyCystic Fibrosis Foundation, Bethesda, MD, United States.
Amy HoffmanCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States.
David P NicholsCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, United States; Department of Pediatrics, University of Washington, Seattle, WA, United States.

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CFUM1HL119073 · NHLBI · UNIVERSITY OF WASHINGTON · PI GOSS, CHRISTOPHER HOOPER, SINGH, PRADEEP K · 2013 to 2017
$4.8M
A Phase 1b, Multi-center Study of IV Gallium Nitrate in Patients with Cystic Fibrosis who are colonized with Nontuberculosis Mycobacterium (The ABATE Study).R01FD006848 · FDA · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, JERRY A NICK · 2020 to 2026
$3.1M
Phase 2 Study of Intravenous Gallium Nitrate in the Treatment of Cystic FibrosisR01FD003704 · FDA · UNIVERSITY OF WASHINGTON · PI GOSS, CHRISTOPHER HOOPER · 2009 to 2018
$2.0M
FDA HHS R01 FD003704FDA HHS R01 FD006848NCATS NIH HHS UL1 TR000423NHLBI NIH HHS UM1 HL119073NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic significantly impacted CF clinical research within the Cystic Fibrosis Foundation Therapeutics Development Network (CFF TDN). A Research Electronic Data Capture (REDCap) survey was developed and sent to network sites to monitor and understand the impact on research teams, ongoing and anticipated clinical research, and specific clinical and research procedures. Key findings indicated an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction. These trends steadily improved over the months as research activities began to recover across the TDN. While SARS-CoV-2 created a significant challenge it also highlights new opportunities to expand CF research with greater focus on data collection outside of research centers and increased access for remote participation.

Indexed as

Biomedical ResearchCOVID-19Cystic FibrosisFoundationsHumansResearch DesignSpirometrySurveys and QuestionnairesClinical researchCoronavirusCystic fibrosisSARS-CoV-2

Identifiers

PMID33349583
PMCPMC7834129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.