Evidence map›Paper›PMID 33349580›Full record

ReviewParkinsonism & related disorders2020

Do caffeine and more selective adenosine A

Jiang-Fan Chen, Michael A Schwarzschild

Open access · bronzeAbstract readReview
In one paragraph

Review in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Discovery of novel AMolecular diversity · 2025
    Article
  6. Review
  7. Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025
    Review
  8. Review
  9. Review
  10. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Life style and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  15. Review
  16. The Pharmacological Potential of Adenosine AMolecules (Basel, Switzerland) · 2022
    Review
  17. ACurrent medicinal chemistry · 2022
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jiang-Fan ChenThe Molecular Neuropharmacology Lab, School of Optometry & Ophthalmology and the State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou Medical University, Wenzhou, PR China. Electronic address: chenjf555@gmail.com.
Michael A SchwarzschildDepartment of Neurology, Massachusetts General Hospital, Boston, USA. Electronic address: michaels@helix.mgh.harvard.edu.
Massachusetts General Hospital · USWenzhou Medical University · CN

Funding

Translational Foundation of Adenosine Antagonist Use for DyskinesiasR01NS054978 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2006 to 2010
$2.1M
Urate-LRRK2 interactions in Parkinson's diseaseR01NS110879 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2019 to 2023
$2.0M
Novel Neuroprotection by Caffeine in Parkinson's DiseaseR01ES010804 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2001 to 2005
$1.7M
A2A Adenosine Receptors in Psychostimulant SensitizationR01DA013508 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2001 to 2005
$1.5M
Pursuing purinergic pathways to clinical trials for Parkinson's diseaseK24NS060991 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2008 to 2012
$954k
Targeting Adenosine A2A Receptors in Parkinson's DiseaseR13NS055597 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2006 to 2006
$10k
NIDA NIH HHS R01 DA013508NIEHS NIH HHS R01 ES010804NINDS NIH HHS K24 NS060991NINDS NIH HHS R01 NS054978NINDS NIH HHS R01 NS110879NINDS NIH HHS R13 NS055597
6 · The paper itself

Abstract

The adenosine A

Indexed as

AdenosineAdenosine A2 Receptor AntagonistsAnimalsCaffeineDisease Models, AnimalHumansNeuroprotective AgentsParkinson DiseaseReceptor, Adenosine A2AAdenosineAdenosine A2 Receptor AntagonistsCaffeineNeuroprotective AgentsReceptor, Adenosine A2AA(2A) receptorsAdenosineCaffeineNeuroprotectionParkinson's disease

Identifiers

PMID33349580
PMCPMC8102090
OpenAlexW3115387435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.