ArticleUltrasound in medicine & biology2021
Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom.
Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Delivery of Cavitation Therapy With a Modified Clinical Scanner: In Vitro Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Histotripsy and Catheter-Directed Lytic: Efficacy in Highly Retracted Porcine Clots In Vitro.Ultrasound in medicine & biology · 2024Article
- Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Quantifying the Effect of Acoustic Parameters on Temporal and Spatial Cavitation Activity: Gauging Cavitation Dose.Ultrasound in medicine & biology · 2023Article
- Passive Cavitation Imaging Artifact Reduction Using Data-Adaptive Spatial Filtering.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter.Scientific reports · 2023Article
- Impact of Perfluoropentane Microdroplets Diameter and Concentration on Acoustic Droplet Vaporization Transition Efficiency and Oxygen Scavenging.Pharmaceutics · 2022Article
- Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound.Cancers · 2022Review
- (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.PloS one · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The EkoSonic endovascular system has been cleared by the U.S. Food and Drug Administration for the controlled and selective infusion of physician specified fluids, including thrombolytics, into the peripheral vasculature and the pulmonary arteries. The objective of this study was to explore whether this catheter technology could sustain cavitation nucleated by infused Definity, to support subsequent studies of ultrasound-mediated drug delivery to diseased arteries. The concentration and attenuation spectroscopy of Definity were assayed before and after infusion at 0.3, 2.0 and 4.0 mL/min through the EkoSonic catheter. PCI was used to map and quantify stable and inertial cavitation as a function of Definity concentration in a flow phantom mimicking the porcine femoral artery. The 2.0 mL/min infusion rate yielded the highest surviving Definity concentration and acoustic attenuation. Cavitation was sustained throughout each 15 ms ultrasound pulse, as well as throughout the 3 min infusion. These results demonstrate a potential pathway to use cavitation nucleation to promote drug delivery with the EkoSonic endovascular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.