ArticleeLife2020
Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep.Brain communications · 2025Article
- Article
- Triboelectric nanogenerators for self-powered neurostimulation.Nano research · 2024Article
- The critical dynamics of hippocampal seizures.Nature communications · 2024Article
- Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures.Heliyon · 2024Article
- Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy.Neuroscience bulletin · 2024Article
- Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams.Science advances · 2024Article
- Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research.Cellular and molecular neurobiology · 2024Review
- Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI.Frontiers in neuroimaging · 2024Article
- Wake slow waves in focal human epilepsy impact network activity and cognition.Nature communications · 2023Article
- Optogenetic and chemogenetic manipulation of seizure threshold in mice.STAR protocols · 2023Article
- Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy.Frontiers in cellular neuroscience · 2023Article
- GABACurrent neuropharmacology · 2022Review
- Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures.Journal of molecular neuroscience : MN · 2022Article
- Article
- Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances.Biomedical journal · 2022Review
- Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus.BMC biology · 2022Article
- Epileptic seizures and link to memory processes.AIMS neuroscience · 2022Article
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11 authors at 1 institution in 1 country.
Funding
Abstract
Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established the efficacy of optogenetic and electrical low-frequency stimulation (LFS) in interfering with seizure generation in a mouse model of MTLE. Specifically, we applied LFS in the sclerotic hippocampus to study the effects on spontaneous subclinical and evoked generalized seizures. We found that stimulation at 1 Hz for 1 hr resulted in an almost complete suppression of spontaneous seizures in both hippocampi. This seizure-suppressive action during daily stimulation remained stable over several weeks. Furthermore, LFS for 30 min before a pro-convulsive stimulus successfully prevented seizure generalization. Finally, acute slice experiments revealed a reduced efficacy of perforant path transmission onto granule cells upon LFS. Taken together, our results suggest that hippocampal LFS constitutes a promising approach for seizure control in MTLE.
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