Evidence map›Paper›PMID 33349289›Full record

ReviewJournal of developmental origins of health and disease2021

Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging.

G D Clarke, J Li, A H Kuo, A J Moody, P W Nathanielsz

Open access · greenAbstract readReview
In one paragraph

Review in Journal of developmental origins of health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Age-related ceRNA networks in adultFrontiers in genetics · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

G D ClarkeDepartment of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0003-4559-6437
J LiDepartment of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
A H KuoDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
A J MoodyDepartment of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
P W NathanielszDepartment of Animal Science, University of Wyoming, Laramie, WY, USA.
The University of Texas Health Science Center at San Antonio · USMassachusetts General Hospital · USUniversity of Wyoming · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
PARTURITION AND FETAL PRIMATE HYPOTHALAMIC FUNCTIONP01HD021350 · NICHD · UNIVERSITY OF WYOMING · PI JANSSON, THOMAS · 1987 to 2018
$19.9M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
TRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4M
Developmental Programming by Mismatch of Pre- and Postnatal NutritionR24OD011183 · OD · UNIVERSITY OF WYOMING · PI NATHANIELSZ, PETER W. · 2012 to 2015
$2.9M
Multidisciplinary Training Program in Human ImagingT32EB000817 · NIBIB · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARKE, GEOFFREY DAVID · 2004 to 2008
$967k
Research Training for Radiology Residents, San Antonio, TexasR25EB016631 · NIBIB · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2014 to 2018
$335k
NIA NIH HHS T32 AG021890NIA NIH HHS U19 AG057758NIBIB NIH HHS R25 EB016631NIBIB NIH HHS T32 EB000817NICHD NIH HHS P01 HD021350NIH HHS P51 OD011133NIH HHS R24 OD011183
6 · The paper itself

Abstract

Cardiovascular diseases (CVD) are important consequences of adverse perinatal conditions such as fetal hypoxia and maternal malnutrition. Cardiac magnetic resonance imaging (CMR) can produce a wealth of physiological information related to the development of the heart. This review outlines the current state of CMR technologies and describes the physiological biomarkers that can be measured. These phenotypes include impaired ventricular and atrial function, maladaptive ventricular remodeling, and the proliferation of myocardial steatosis and fibrosis. The discussion outlines the applications of CMR to understanding the developmental pathways leading to impaired cardiac function. The use of CMR, both in animal models of developmental programming and in human studies, is described. Specific examples are given in a baboon model of intrauterine growth restriction (IUGR). CMR offers great potential as a tool for understanding the sequence of dysfunctional adaptations of developmental origin that can affect the human cardiovascular system.

Indexed as

AgingAnimalsFemaleFetal Growth RetardationHeartHumansMagnetic Resonance ImagingPregnancycardiac MRIdevelopmental programmingHeart diseaseventricular remodeling

Identifiers

PMID33349289
PMCPMC7987688
OpenAlexW3115254916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.