SynthesisBMC medicine2020
Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.
Synthesis in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation.Annals of medicine · 2026Trial
- Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results.Blood advances · 2025Trial
- Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.American journal of hematology · 2025Trial
- Aging with Thalassemia and Sickle Cell Disease: A Gerontological Model of Accelerated Multimorbidity and Function-Centered Care Beyond Midlife.Mediterranean journal of hematology and infectious diseases · 2026Review
- Neurocognitive functioning of patients with sickle cell disease in low- and middle-income countries.Blood global hematology · 2025Article
- Parental Adverse Childhood Experiences and Health Care Use Among Children With Sickle Cell Disease.JAMA network open · 2025Article
- The association between preoperative lacunar infarcts and postoperative delirium in elderly patients undergoing major abdominal surgery: a prospective cohort study.Aging clinical and experimental research · 2025Review
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.bioRxiv : the preprint server for biology · 2024Article
- Silent Cerebral Infarcts in Adults With Sickle Cell Disease: Expanding Beyond Childhood Borders.Neurology · 2024Article
- Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurologic Events.Neurology. Clinical practice · 2024Article
- Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia.British journal of haematology · 2023Article
- Article
- Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.Blood advances · 2023Article
- Cognitive-motor dual-task interference in adults with sickle cell disease.Gait & posture · 2023Article
- Neuroimaging and Cognitive Function in Sickle Cell Disease: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Does TGFBR3 Polymorphism Increase the Risk of Silent Cerebral Infarction in Egyptian Children with Sickle Cell Disease?Indian journal of pediatrics · 2023Article
- Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study.Neuroradiology · 2023Article
- Grand challenges in pediatric stroke.Frontiers in stroke · 2023Article
- Effect of Blood Transfusion on Cerebral Hemodynamics and Vascular Topology Described by Computational Fluid Dynamics in Sickle Cell Disease Patients.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSilent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences.
methodsThe databases of Embase, MEDLINE ALL via Ovid, Web of Science Core Collection, Cochrane Central Register of Trials via Wiley and Google Scholar were searched from inception to June 1, 2019.
resultsThe search yielded 651 results of which 69 studies met the eligibility criteria. The prevalence of SCIs in patients with SCD ranges from 5.6 to 80.6% with most studies reported in the 20 to 50% range. The pooled prevalence of SCIs in HbSS and HbSβ
conclusionsThis systematic review and meta-analysis shows SCIs are common in patients with SCD. No clear risk factors for their development were identified. Larger, prospective and controlled clinical, neuropsychological and neuroimaging studies are needed to understand how SCD and SCIs affect cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.