Evidence map›Paper›PMID 33349112›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Inhibited microRNA-494-5p promotes proliferation and suppresses senescence of nucleus pulposus cells in mice with intervertebral disc degeneration by elevating TIMP3.

Gang Chen, Xiaopeng Zhou, Hao Li, Zhengkuan Xu

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gang ChenOrthopedic Department, The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou, Zhejiang, China.
Xiaopeng ZhouOrthopedic Department, The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou, Zhejiang, China.
Hao LiOrthopedic Department, The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou, Zhejiang, China.
Zhengkuan XuOrthopedic Department, The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou, Zhejiang, China.
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been unraveled that microRNAs (miRNAs) played crucial roles in processes of human diseases, while the role of miR-494-5p in intervertebral disc degeneration (IDD) remains scarcely studied. We aimed to investigate the mechanisms of miR-494-5p in IDD with the involvement of tissue inhibitor of metalloproteinase 3 (TIMP3). Expression of miR-494-5p and TIMP3 in IDD clinical specimens was assessed. The IDD models were established by needle punching, which were then injected with low expression of miR-494-5p or TIMP3 overexpression lentivirus to observe their effects on pathology and apoptosis in IDD mice. The nucleus pulposus cells were isolated and, respectively, treated with miR-494-5p inhibitor or TIMP3 overexpression plasmid to determine the viability, apoptosis, and senescence

Indexed as

AdultAnimalsApoptosisCell ProliferationCells, CulturedCellular SenescenceDown-RegulationExtracellular MatrixHumansIntervertebral DiscIntervertebral Disc DegenerationMiceMicroRNAsNucleus PulposusTissue Inhibitor of Metalloproteinase-3Up-RegulationMicroRNAsMirn494 microRNA, mouseTIMP3 protein, humanTissue Inhibitor of Metalloproteinase-3cellular senescencedifferentiationIntervertebral disc degenerationMicroRNA-494-5pnucleus pulposus cellsproliferationtissue inhibitor of metalloproteinase 3

Identifiers

PMID33349112
PMCPMC7849772
OpenAlexW3113912305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.