Evidence map›Paper›PMID 33348809›Full record

ArticleCancers2020

Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.

Loryn Holokai, Jayati Chakrabarti, Joanne Lundy, Daniel Croagh, Pritha Adhikary, Scott S Richards, Chantal Woodson, Nina Steele, Robert Kuester, Aaron Scott and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
  4. Trial
  5. Review
  6. Review
  7. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review
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  12. Article
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  16. Tumor organoid-immune cell co-culture systems for precision oncology.Frontiers in cell and developmental biology · 2026
    Review
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  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Loryn HolokaiDepartment of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, OH 45220, USA.
Jayati ChakrabartiDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85719, USA.ORCID 0000-0003-2265-4657
Joanne LundyCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Daniel CroaghDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3800, Australia.
Pritha AdhikaryDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85719, USA.
Scott S RichardsDepartment of Gastroenterology and Hepatology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Chantal WoodsonDepartment of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, OH 45220, USA.
Nina SteeleDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Robert KuesterDepartment of Gastroenterology and Hepatology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Aaron ScottDivision of Hematology and Oncology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.ORCID 0000-0002-0301-3072
Mohammad KhreissDivision of Hematology and Oncology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Timothy FrankelDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Juanita MerchantDepartment of Gastroenterology and Hepatology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Brendan J JenkinsCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Jiang WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0002-6899-1678
Rachna T ShroffDivision of Hematology and Oncology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Syed A AhmadDepartment of Surgery, Division of Surgical Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.
Yana ZavrosDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85719, USA.
University of Arizona · USUniversity of Cincinnati · USHudson Institute of Medical Research · AUUniversity of Michigan · USMonash Health · AUUniversity of Cincinnati Medical Center · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
The role of Hedgehog Signaling in gastric tissue repair and regenerationR01DK083402 · NIDDK · UNIVERSITY OF CINCINNATI · PI ZAVROS, YANA · 2011 to 2019
$3.7M
MDSC Polarization and Helicobacter-Induced Gastric MetaplasiaR01DK118563 · NIDDK · UNIVERSITY OF ARIZONA · PI MERCHANT, JUANITA L. · 2018 to 2021
$1.4M
Molecular Mechanisms of Premalignancy in Response to Helicobacter pylori InfectionF31DK120206 · NIDDK · UNIVERSITY OF CINCINNATI · PI HOLOKAI, LORYN · 2018 to 2018
$35k
Goldman Pancreatic Cancer Grant, University of Cincinnati No grant numberNIDDK NIH 1 F31 DK120206-01NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK118563NIH HHS 5 T32 ES7250-29NIH NIDDK R01DK083402
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

myeloid derived suppressor cells (MDSCs)organoid/immune-cell co-cultureorganoidspancreatic ductal adenocarcinoma (PDAC)PD-L1

Identifiers

PMID33348809
PMCPMC7766822
OpenAlexW3111944178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.