Evidence map›Paper›PMID 33348757›Full record

ArticleInternational journal of molecular sciences2020

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-

Łukasz Szczukowski, Edward Krzyżak, Adrianna Zborowska, Patrycja Zając, Katarzyna Potyrak, Krzysztof Peregrym, Benita Wiatrak, Aleksandra Marciniak, Piotr Świątek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  9. Article
  10. NewInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. A New N-Substituted 1International journal of molecular sciences · 2021
    Article
  14. Editorial for Special Issue "Bioactive Oxadiazoles".International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Łukasz SzczukowskiDepartment of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0002-9768-6269
Edward KrzyżakDepartment of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.ORCID 0000-0002-5000-2448
Adrianna ZborowskaStudent Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Patrycja ZającStudent Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Katarzyna PotyrakStudent Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Krzysztof PeregrymStudent Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Benita WiatrakDepartment of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0002-1404-2274
Aleksandra MarciniakDepartment of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.ORCID 0000-0003-2225-7897
Piotr ŚwiątekDepartment of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0003-4613-025X
Wroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treatment of different chronic inflammatory disorders is strongly restricted by their serious gastrointestinal adverse effects. Therefore, there is still an urgent need to search for new, safe, and efficient anti-inflammatory agents. Previously, we have reported the Mannich base-type derivatives of pyrrolo[3,4-

Indexed as

Drug DesignAntioxidantsCatalytic DomainCell LineCell SurvivalCircular DichroismCyclooxygenase 2Cyclooxygenase 2 InhibitorsFemaleFibroblastsHumansInhibitory Concentration 50Mannich BasesMiddle AgedMolecular Docking SimulationMolecular Structure1,3,4-oxadiazoleAntioxidantsCyclooxygenase 2Cyclooxygenase 2 InhibitorsMannich BasesOxadiazolesPTGS2 protein, humanPyridazinesPyrrolespyrrolo(3,4-d)pyridazinoneSerum Albumin, Bovine1,3,4-oxadiazoleanti-inflammatory activityanti-oxidant agentsDNA protectiondouble pharmacophore approachmolecular dockingselective COX-2 inhibitors

Identifiers

PMID33348757
PMCPMC7766220
OpenAlexW3110751516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.