Evidence map›Paper›PMID 33348670›Full record

ArticleInternational journal of molecular sciences2020

Effects of Fe

Davide Doni, Leonardo Passerini, Gérard Audran, Sylvain R A Marque, Marvin Schulz, Javier Santos, Paola Costantini, Marco Bortolus, Donatella Carbonera

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Davide DoniDepartment of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy.
Leonardo PasseriniDepartment of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy.
Gérard AudranInstitut de Chimie Radicalaire, Aix Marseille Universitè, CNRS, ICR, UMR 7273, Case 551, Ave Escadrille Normandie Niemen, CEDEX 20, 13397 Marseille, France.
Sylvain R A MarqueInstitut de Chimie Radicalaire, Aix Marseille Universitè, CNRS, ICR, UMR 7273, Case 551, Ave Escadrille Normandie Niemen, CEDEX 20, 13397 Marseille, France.
Marvin SchulzInstitut de Chimie Radicalaire, Aix Marseille Universitè, CNRS, ICR, UMR 7273, Case 551, Ave Escadrille Normandie Niemen, CEDEX 20, 13397 Marseille, France.
Javier SantosDepartamento de Química Biológica, Instituto de Biociencias, Biotecnología y Biomedicina (iB3-UBA), Facultad de Ciencia Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160-Ciudad Universitaria, 1428EGA CONICET, Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.ORCID 0000-0002-1140-8234
Paola CostantiniDepartment of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy.
Marco BortolusDepartment of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy.ORCID 0000-0002-6033-6521
Donatella CarboneraDepartment of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy.
University of Padua · ITCentre National de la Recherche Scientifique · FRConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca NExuS
6 · The paper itself

Abstract

Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich's ataxia. Frataxin's actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the biosynthetic iron-sulphur cluster (ISC) machinery, and several authors have pointed out that it also participates in iron homeostasis. In this work, we use site-directed spin labeling coupled to electron paramagnetic resonance (SDSL EPR) to add new information on the effects of ferric and ferrous iron binding on the properties of human frataxin

Indexed as

Spin LabelsCircular DichroismElectron Spin Resonance SpectroscopyFerric CompoundsFerrous CompoundsFrataxinHumansHydrogen-Ion ConcentrationIronIron-Binding ProteinsProtein Aggregation, PathologicalProtein BindingProtein ConformationSpectrometry, FluorescenceFerric CompoundsFerrous CompoundsFrataxinIronIron-Binding ProteinsSpin LabelsCDEPRFe-S cluster assembly machineryfluorescencefrataxiniron

Identifiers

PMID33348670
PMCPMC7766144
OpenAlexW3111681411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.