Evidence map›Paper›PMID 33348645›Full record

ReviewMicroorganisms2020

Multifunctional Amyloids in the Biology of Gram-Positive Bacteria.

Ana Álvarez-Mena, Jesús Cámara-Almirón, Antonio de Vicente, Diego Romero

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Anti-Biofilm Molecules Targeting Functional Amyloids.Antibiotics (Basel, Switzerland) · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana Álvarez-MenaInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora"-Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur, 31 (Campus Universitario de Teatinos), 29071 Malaga, Spain.
Jesús Cámara-AlmirónInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora"-Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur, 31 (Campus Universitario de Teatinos), 29071 Malaga, Spain.
Antonio de VicenteInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora"-Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur, 31 (Campus Universitario de Teatinos), 29071 Malaga, Spain.ORCID 0000-0003-2716-9861
Diego RomeroInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora"-Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur, 31 (Campus Universitario de Teatinos), 29071 Malaga, Spain.ORCID 0000-0002-2052-6515
Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora" · ES

Funding

H2020 European Research Council BacBio 637971Ministerio de Ciencia, Innovación y Universidades AGL2016-78662-RMinisterio de Ciencia, Innovación y Universidades PID2019-107724GB-I00
6 · The paper itself

Abstract

Since they were discovered, amyloids have proven to be versatile proteins able to participate in a variety of cellular functions across all kingdoms of life. This multitask trait seems to reside in their ability to coexist as monomers, aggregates or fibrillar entities, with morphological and biochemical peculiarities. It is precisely this common molecular behaviour that allows amyloids to cross react with one another, triggering heterologous aggregation. In bacteria, many of these functional amyloids are devoted to the assembly of biofilms by organizing the matrix scaffold that keeps cells together. However, consistent with their notion of multifunctional proteins, functional amyloids participate in other biological roles within the same organisms, and emerging unprecedented functions are being discovered. In this review, we focus on functional amyloids reported in gram-positive bacteria, which are diverse in their assembly mechanisms and remarkably specific in their biological functions that they perform. Finally, we consider cross-seeding between functional amyloids as an emerging theme in interspecies interactions that contributes to the diversification of bacterial biology.

Indexed as

Bacillusbiofilmfunctional amyloidsgram-postive bacteriamicrobial ecologypathogenesis

Identifiers

PMID33348645
PMCPMC7766987
OpenAlexW3113262829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.