Evidence map›Paper›PMID 33348537›Full record

ReviewMolecules (Basel, Switzerland)2020

Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies.

Maarten Honing, Chris Martini, Monique van Velzen, Marieke Niesters, Albert Dahan, Martijn Boon

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maarten HoningDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9747-6966
Chris MartiniDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Monique van VelzenDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0289-6432
Marieke NiestersDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Albert DahanDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Martijn BoonDepartment of Anesthesiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2724-9581
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.

Indexed as

AcetylcholineAnesthesia, GeneralAnesthetics, GeneralCarotid BodyCholinergic AgentsCholinergic NeuronsDelayed Emergence from AnesthesiaHumansHypnotics and SedativesMuscle Relaxants, CentralPropofolReceptors, NicotinicRespirationRespiration, ArtificialAcetylcholineAnesthetics, GeneralCholinergic AgentsHypnotics and SedativesMuscle Relaxants, CentralPropofolReceptors, Nicotinicanesthesiacholinergic transmissionmuscle relaxantsperipheral chemosensitivity

Identifiers

PMID33348537
PMCPMC7765955
OpenAlexW3112716915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.