ArticlePhysics in medicine and biology2021
Fat and fibrosis as confounding cofactors in viscoelastic measurements of the liver.
Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 4 citations in OpenAlex.
- Frequency and Direction-Dependent Shear-Wave Responses in Ex Vivo Tissues Measured by a Time-of-Flight Device.Bioengineering (Basel, Switzerland) · 2026Article
- Investigating confounding factors in shear wave speed measurements of fibrotic liver tissues: a computer simulation study.Physical and engineering sciences in medicine · 2026Article
- Influence variables of ultrasound-derived fat fraction in liver fat content measurement: preprandial and postprandial states.Abdominal radiology (New York) · 2025Article
- Laryngeal and pleural ultrasound and acoustic radiation force impulse elastography in dogs with brachycephalic obstructive airway syndrome.Scientific reports · 2025Article
- Towards linking histological changes to liver viscoelasticity: a hybrid analytical-computational micromechanics approach.Physics in medicine and biology · 2025Article
- Integrated Difference Autocorrelation: A Novel Approach to Estimate Shear Wave Speed in the Presence of Compression Waves.IEEE transactions on bio-medical engineering · 2025Article
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- Article
- Characterizing dispersion in bovine liver using ARFI-based shear wave rheometry.Biomedical physics & engineering express · 2024Article
- Multiparametric quantification and visualization of liver fat using ultrasound.WFUMB ultrasound open · 2024Article
- Advanced fibrosis leads to overestimation of steatosis with quantitative ultrasound in individuals without hepatic steatosis.Ultrasonography (Seoul, Korea) · 2024Article
- Article
- Accuracy Rate of Shear Wave Elastography in Detecting the Liver Fibrosis in Overweight and Obese Children with Hepatosteatosis.Turkish archives of pediatrics · 2023Article
- Comprehensive experimental assessments of rheological models' performance in elastography of soft tissues.Acta biomaterialia · 2022Article
- Validations of the microchannel flow model for characterizing vascularized tissues.European journal of mechanics. B, Fluids · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Elastography provides significant information on staging of fibrosis in patients with liver disease and may be of some value in assessing steatosis. However, there remain questions as to the role of steatosis and fibrosis as cofactors influencing the viscoelastic measurements of liver tissues, particularly shear wave speed (SWS) and shear wave attenuation (SWA). In this study, by employing the theory of composite elastic media as well as two independent experimental measurements on oil-in-gelatin phantoms and also finite element simulations, it is consistently shown that fat and fibrosis jointly influence the SWS and SWA measurements. At a constant level of fat, fibrosis stages can influence the SWA by factors of 2-4. Moreover, the rate of increase in SWA with increasing fat is strongly influenced by the stages of fibrosis; softer background cases (low fibrosis stages) have higher rate of SWA increase with fat than those with stiffer moduli (higher fibrosis stages). Meanwhile, SWS results are influenced by the presence of fat, however the degree of variability is more subtle. The results indicate the importance of jointly considering fat and fibrosis as contributors to SWS and SWA measurements in complex liver tissues and in the design and interpretation of clinical trials.
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