Evidence map›Paper›PMID 33347809›Full record

ArticleThe lancet. Diabetes & endocrinology2021

Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study.

Cari M Kitahara, Dagrun Slettebø Daltveit, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Ylva Trolle Lagerros, Laura Madanat-Harjuoja, Tuija Männistö and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Epidemiology of Thyroid Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  11. Article
  12. Long noncoding RNAGland surgery · 2021
    Article
  13. Best Achievements in Clinical Thyroidology in 2020.Endocrinology and metabolism (Seoul, Korea) · 2021
    Review
  14. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 5 countries.

Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. Electronic address: kitaharac@mail.nih.gov.
Dagrun Slettebø DaltveitDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Anders EkbomDepartment of Medicine, Division of Clinical Epidemiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Anders EngelandDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.
Mika GisslerFinnish Institute for Health and Welfare, Helsinki, Finland; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Ingrid GlimeliusDepartment of Medicine, Division of Clinical Epidemiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Tom GrotmolCancer Registry of Norway, Oslo, Norway.
Ylva Trolle LagerrosDepartment of Medicine, Division of Clinical Epidemiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Laura Madanat-HarjuojaCancer Society of Finland, Finnish Cancer Registry, Helsinki, Finland; Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tuija MännistöNorthern Finland Laboratory Center NordLab, Oulu, Finland.
Henrik Toft SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Rebecca TroisiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Tone BjørgeDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway.
Division of Cancer Epidemiology and GeneticsKarolinska Institutet · SEKarolinska University Hospital · SEUniversity of Bergen · NOAarhus University Hospital · DKCancer Registry of Norway · NONordLab · FINorwegian Institute of Public Health · NOUniversity of Helsinki · FI

Funding

Studies of other risk factors for radiosensitive tumorsZIACP010219 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2011 to 2025
$6.0M
Intramural NIH HHS ZIA CP010219
6 · The paper itself

Abstract

backgroundThyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with increased risk of thyroid cancer have been identified.

methodsIn this population-based nested case-control study we used registry data from four Nordic countries to assess thyroid cancer risk in offspring in relation to maternal medical history, pregnancy complications, and birth characteristics. Patient with thyroid cancer (cases) were individuals born and subsequently diagnosed with first primary thyroid cancer from 1973 to 2013 in Denmark, 1987 to 2014 in Finland, 1967 to 2015 in Norway, or 1973 to 2014 in Sweden. Each case was matched with up to ten individuals without thyroid cancer (controls) based on birth year, sex, country, and county of birth. Cases and matched controls with a previous diagnosis of any cancer, other than non-melanoma skin cancer, at the time of thyroid cancer diagnosis were excluded. Cases and matched controls had to reside in the country of birth at the time of thyroid cancer diagnosis. Conditional logistic regression models were used to calculate odds ratios (ORs) with 95% CIs.

resultsOf the 2437 cases, 1967 (81·4%) had papillary carcinomas, 1880 (77·1%) were women, and 1384 (56·7%) were diagnosed before age 30 years (range 0-48). Higher birth weight (OR per kg 1·14 [95% CI 1·05-1·23]) and congenital hypothyroidism (4·55 [1·58-13·08]); maternal diabetes before pregnancy (OR 1·69 [0·98-2·93]) and postpartum haemorrhage (OR 1·28 [1·06-1·55]); and (from registry data in Denmark) maternal hypothyroidism (18·12 [10·52-31·20]), hyperthyroidism (11·91 [6·77-20·94]), goiter (67·36 [39·89-113·76]), and benign thyroid neoplasms (22·50 [6·93-73·06]) were each associated with an increased risk of thyroid cancer in offspring.

interpretationIn-utero exposures, particularly those related to maternal thyroid disorders, might have a long-term influence on thyroid cancer risk in offspring.

fundingIntramural Research Program of the National Cancer Institute (National Institutes of Health).

Indexed as

Case-Control StudiesFemaleHumansMaleMaternal HealthPregnancyPrenatal Exposure Delayed EffectsRisk FactorsScandinavian and Nordic CountriesThyroid Neoplasms

Identifiers

PMID33347809
PMCPMC7875310
OpenAlexW3113169666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.