Evidence map›Paper›PMID 33347626›Full record

ArticleThe EMBO journal2021

Nucleolar c-Myc recruitment by a Vibrio T3SS effector promotes host cell proliferation and bacterial virulence.

Maozhi Hu, Yibei Zhang, Dan Gu, Xiang Chen, Matthew K Waldor, Xiaohui Zhou

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Article
  5. Gut metabolite L-lactate supportsProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Review
  7. Frontiers in microbiology · 2024
    Article
  8. Review
  9. Microbial genomics · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Comparative Metabolomics and Proteomics RevealFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maozhi HuDepartment of Pathobiology and Veterinary Science, University of Connecticut, Mansfield, CT, USA.
Yibei ZhangDepartment of Pathobiology and Veterinary Science, University of Connecticut, Mansfield, CT, USA.
Dan GuDepartment of Pathobiology and Veterinary Science, University of Connecticut, Mansfield, CT, USA.
Xiang ChenDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1843-7000
Xiaohui ZhouDepartment of Pathobiology and Veterinary Science, University of Connecticut, Mansfield, CT, USA.ORCID 0000-0003-3205-4743
Mansfield University · USBrigham and Women's Hospital · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Howard Hughes Medical Institute (HHMI)NIAID NIH HHS R01 AI042347University of Connecticut Research Funds
6 · The paper itself

Abstract

Pathogen type 3 secretion systems (T3SS) manipulate host cell pathways by directly delivering effector proteins into host cells. In Vibrio parahaemolyticus, the leading cause of bacterial seafood-borne diarrheal disease, we showed that a T3SS effector, VgpA, localizes to the host cell nucleolus where it binds Epstein-Barr virus nuclear antigen 1-binding protein 2 (EBP2). An amino acid substitution in VgpA (VgpA

Indexed as

AnimalsBacterial ProteinsCaco-2 CellsCarrier ProteinsCell Line, TumorCell NucleolusCell ProliferationEpithelial CellsEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensGene Expression Regulation, BacterialHerpesvirus 4, HumanHumansProto-Oncogene Proteins c-mycRabbitsRNA-Binding ProteinsBacterial ProteinsCarrier ProteinsEBV-encoded nuclear antigen 1Epstein-Barr Virus Nuclear AntigensProto-Oncogene Proteins c-mycRNA-Binding ProteinsRNA, RibosomalType III Secretion Systemsc-MycEBP2effectorproliferationvirulence

Identifiers

PMID33347626
PMCPMC7809790
OpenAlexW3115262399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.