ReviewThe Journal of physiology2021
Silent hypoxaemia in COVID-19 patients.
Open access · bronzeAbstract readReview
In one paragraph
Review in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 2% of its field
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Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Do Differences in Skin Pigmentation Affect Detection of Hypoxemia by Pulse Oximetry: A Systematic Review of the Literature.Clinical nursing research · 2025Pooled it
- The normal distribution of the hypoxic ventilatory response and methodological impacts: a meta-analysis and computational investigation.The Journal of physiology · 2023Pooled it
- Pharmacological management of seizures in patients with COVID-19: a systematic review.AAS open research · 2021Pooled it
- Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.Experimental neurology · 2022Trial
- Long-term impacts of COVID-19 on systemic inflammation and control of breathing reflexes: an observational cohort study.Respiratory research · 2026Observational
- Extracorporeal membrane oxygenation with single-site dual-lumen in a patient with SARS-CoV-2-associated acute respiratory distress syndrome: a case report.Frontiers in medicine · 2026Article
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Advances in gas-exchange physiology and pathophysiology.ERS monograph · 2025Article
- Oxygen-dependent functional brain haemodynamic response.Biomedical optics express · 2025Article
- Happy Hypoxia With SARS-CoV-2 Pneumonitis: A Life-Threatening Case of a Medical Doctor.Cureus · 2025Article
- Smart oxygen monitoring in hospitals: a pilot study during COVID-19.Scientific reports · 2025Article
- Reframing SpOFrontiers in physiology · 2025Review
- The association between vital signs at hospital admission and adverse outcomes in patients with COVID-19: a retrospective cohort study.Frontiers in medicine · 2025Article
- Oxygenation indices and early prediction of outcome in hypoxemic patients with COVID-19 pneumonia requiring noninvasive respiratory support in pulmonary intermediate care unit.Pneumonia (Nathan Qld.) · 2024Article
- Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms.Molecular psychiatry · 2024Article
- COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator.Biological cybernetics · 2024Article
- Rapid triage and transfer system for patients with proven Covid-19 at emergency department.Journal of applied biomedicine · 2024Article
- Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease.Frontiers in immunology · 2024Review
- Clinical Presentation and Outcomes of Hospitalized Patients with Chronic Kidney Disease and COVID-19 Variant Omicron.Therapeutics and clinical risk management · 2024Article
- Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 10 institutions in 3 countries.
Tatum S SimonsonDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.ORCID 0000-0003-4062-2587
Tracy L BakerDepartment of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA.ORCID 0000-0001-9047-3052
Robert B BanzettDivision of Pulmonary, Critical Care, & Sleep Medicine Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3626-5735
Tammie BishopTarget Discovery Institute, University of Oxford, Oxford, UK.ORCID 0000-0003-3308-9139
Jerome A DempseyDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin -, Madison, WI, USA.
Jack L FeldmanDepartment of Neurobiology, University of California, Los Angeles, CA, USA.ORCID 0000-0003-3692-9412
Patrice G GuyenetDepartment of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-1739-2306
Emma J HodsonThe Francis Crick Institute, London, UK.ORCID 0000-0003-3646-9348
Gordon S MitchellDepartment of Physical Therapy, Center for Respiratory Research and Rehabilitation, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Esteban A MoyaDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Brandon T NokesDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Jeremy E OrrDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Robert L OwensDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Marc PoulinDepartments of Physiology & Pharmacology and Clinical Neurosciences, Cumming School of Medicine and Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-1798-6801
Jean M RawlingDepartments of Family Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-1768-386X
Christopher N SchmicklDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Jyoti J WattersDepartment of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA.
Magdy YounesSleep Disorders Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Atul MalhotraDivision of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
University of California System · USUniversity of Wisconsin–Madison · USUniversity of Calgary · CABeth Israel Deaconess Medical Center · USUniversity of California, Los Angeles · USUniversity of Cambridge · GBUniversity of Florida Health · USUniversity of Manitoba · CAUniversity of Oxford · GBUniversity of Virginia · US
Funding
Neural control of breathingR35HL135779 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2017 to 2023
$5.6MFunctional Dissection of Medullary Respiratory MicrocircuitsR01NS072211 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2010 to 2020
$3.8MIs Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7MSingle Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5MUnderlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4MMechanisms of inactivity-induced respiratory plasticityR01HL105511 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TRACY L · 2011 to 2020
$3.3MThe relationship between sleep apnea and Alzheimer's disease in a unique mouse model: role for microgliaR01HL142752 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TRACY L, WATTERS, JYOTI J · 2019 to 2022
$3.0MTraining in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1MObstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living with HIVR01HL142114 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR, OWENS, ROBERT LLEWELLYN · 2018 to 2021
$2.0MRESPIRATORY CONTROL AND EMOTION REGULATIONR01AT012412 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2022 to 2025
$1.9MAssessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611kIntegrating physiology and genomics to reveal functional adaptation in high-altitK99HL118215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2014 to 2014
$85kNCCIH NIH HHS R01 AT012412NHLBI NIH HHS K24 HL132105NHLBI NIH HHS K99 HL118215NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL105511NHLBI NIH HHS R01 HL142114NHLBI NIH HHS R01 HL142752NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R35 HL135779NHLBI NIH HHS T32 HL134632NIA NIH HHS R01 AG063925NINDS NIH HHS R01 NS072211
Abstract
The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.
Indexed as
COVID-19DyspneaHumansHypoxiaSARS-CoV-2COVID-19dyspnoeahappy hypoxiaSARS-CoV-2silent hypoxaemia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.