Evidence map›Paper›PMID 33347584›Full record

ArticleInternational journal of epidemiology2021

Swedish snus use is associated with mortality: a pooled analysis of eight prospective studies.

Marja Lisa Byhamre, Marzieh Araghi, Lars Alfredsson, Rino Bellocco, Gunnar Engström, Marie Eriksson, Maria Rosaria Galanti, Jan-Håkan Jansson, Anton Lager, Michael Lundberg and 6 more

Abstract read
In one paragraph

Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Snus and Cardiometabolic Health Markers Among Swedish Young Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Marja Lisa ByhamreDepartment of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Marzieh AraghiDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Rino BelloccoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Marie ErikssonDepartment of Statistics, Umeå School of Business, Economics, and Statistics, Umeå University, Umeå, Sweden.
Maria Rosaria GalantiDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Jan-Håkan JanssonDepartment of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Skellefteå, Sweden.
Anton LagerDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Michael LundbergDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Per-Olof ÖstergrenSocial Medicine and Global Health, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ylva Trolle LagerrosDepartment of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Patrik WennbergDepartment of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Cecilia MagnussonDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe health consequences of the use of Swedish snus, including its relationship with mortality, have not been fully established. We investigated the relationship between snus use and all-cause and cause-specific mortality (death due to cardiovascular diseases, cancer diseases and all other reasons, respectively) in a nationwide collaborative pooling project.

methodsWe followed 169 103 never-smoking men from eight Swedish cohort studies, recruited in 1978-2010. Shared frailty models with random effects at the study level were used in order to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of mortality associated with snus use.

resultsExclusive current snus users had an increased risk of all-cause mortality (aHR 1.28, 95% CI 1.20-1.35), cardiovascular mortality (aHR 1.27, 95% CI 1.15-1.41) and other cause mortality (aHR 1.37, 95% CI 1.24-1.52) compared with never-users of tobacco. The risk of cancer mortality was also increased (aHR 1.12, 95% CI 1.00-1.26). These mortality risks increased with duration of snus use, but not with weekly amount.

conclusionsSnus use among men is associated with increased all-cause mortality, cardiovascular mortality, with death from other causes and possibly with increased cancer mortality.

Indexed as

Tobacco, SmokelessHumansMaleProportional Hazards ModelsProspective StudiesSwedenTobacco UseAll-cause mortalitycancer mortalitycardiovascular mortalitymoist oral snuffsmokeless tobaccoSwedish snus

Identifiers

PMID33347584
PMCPMC7825961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.