ArticlePLoS computational biology2020
Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity.PLoS computational biology · 2026Article
- Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops.BMC biology · 2026Article
- Optimization of connectome weights for a neural network model generating both forward and backward locomotion in C. elegans.Scientific reports · 2026Article
- A data-driven biology-based network model reproduces C. elegans premotor neural dynamics.PLoS computational biology · 2025Article
- CeDNe: A multi-scale computational framework for modeling structure-function relationships in thebioRxiv : the preprint server for biology · 2025Article
- Exploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC.eLife · 2025Article
- NeuroSC: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks.bioRxiv : the preprint server for biology · 2025Article
- An inhibitory acetylcholine receptor gates context-dependent mechanosensory processing iniScience · 2024Article
- Innate Orientating Behavior of a Multi-Legged Robot Driven by the Neural Circuits ofBiomimetics (Basel, Switzerland) · 2024Article
- Proper network randomization is key to assessing social balance.Science advances · 2024Article
- An inhibitory acetylcholine receptor gates context dependent mechanosensory processing inbioRxiv : the preprint server for biology · 2024Article
- Article
- Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans.PLoS biology · 2023Article
- A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior.Current biology : CB · 2022Article
- Computational Inference of Synaptic Polarities in Neuronal Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Fixed Point Attractor Theory Bridges Structure and Function inFrontiers in neuroscience · 2022Article
- A Neuromechanical Model of Multiple Network Rhythmic Pattern Generators for Forward Locomotion inFrontiers in computational neuroscience · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Graph theoretical analyses of nervous systems usually omit the aspect of connection polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans is a well-reconstructed directed network, but the signs of its connections are yet to be elucidated. Here, we present the gene expression-based sign prediction of the ionotropic chemical synapse connectome of C. elegans (3,638 connections and 20,589 synapses total), incorporating available presynaptic neurotransmitter and postsynaptic receptor gene expression data for three major neurotransmitter systems. We made predictions for more than two-thirds of these chemical synapses and observed an excitatory-inhibitory (E:I) ratio close to 4:1 which was found similar to that observed in many real-world networks. Our open source tool (http://EleganSign.linkgroup.hu) is simple but efficient in predicting polarities by integrating neuronal connectome and gene expression data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.