ArticlePLoS biology2020
Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 82 citations in OpenAlex.
- Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder.Translational psychiatry · 2023Trial
- Modulating auditory attention and stimulus evaluation in the medial prefrontal cortex: A translational tone approach oddball paradigm in rats.Cognitive, affective & behavioral neuroscience · 2026Article
- Behavioral engagement and stimulus regularities coordinate auditory-prefrontal network activity.PLoS biology · 2026Article
- Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico.PLoS computational biology · 2026Article
- Prediction from Statistical Learning Aids Auditory Scene Analysis.bioRxiv : the preprint server for biology · 2026Article
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- Attenuated inferred-sensory mismatch during masked face recognition in schizophrenia.Frontiers in psychiatry · 2026Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- BROAD-NESS Uncovers Dual-Stream Mechanisms Underlying Predictive Coding in Auditory Memory Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cortical networks with multiple interneuron types generate oscillatory patterns during predictive coding.PLoS computational biology · 2025Article
- Maternal anxiety shapes prediction error responses in the infant brain.Neurophotonics · 2025Article
- Complementary functional profiles of mismatch responses mediated by adaptation and deviance detection point to two distinct auditory short-term memory systems.Journal of neurophysiology · 2025Article
- Auditory cortex neurons that encode negative prediction errors respond to omissions of sounds in a predictable sequence.PLoS biology · 2025Article
- Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli.Research (Washington, D.C.) · 2025Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: "Spectral" and "Nonspectral".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- From psychophysiology to brain imaging: forty-five years MMN history of investigating acoustic change sensitivity.Biologia futura · 2024Review
- Cerebellar interpositus nucleus exhibits time-dependent errors and predictive responses.NPJ science of learning · 2024Article
- Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex.eLife · 2024Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral regularities and reports frequency-specific deviances. Then, more abstract representations in the prefrontal cortex (PFC) allow to detect contextual changes of potential behavioral relevance. However, the precise location and time asynchronies between neuronal correlates underlying this frontotemporal network remain unclear and elusive. Our study presented auditory oddball paradigms along with "no-repetition" controls to record mismatch responses in neuronal spiking activity and local field potentials at the rat medial PFC. Whereas mismatch responses in the auditory system are mainly induced by stimulus-dependent effects, we found that auditory responsiveness in the PFC was driven by unpredictability, yielding context-dependent, comparatively delayed, more robust and longer-lasting mismatch responses mostly comprised of prediction error signaling activity. This characteristically different composition discarded that mismatch responses in the PFC could be simply inherited or amplified downstream from the auditory system. Conversely, it is more plausible for the PFC to exert top-down influences on the AC, since the PFC exhibited flexible and potent predictive processing, capable of suppressing redundant input more efficiently than the AC. Remarkably, the time course of the mismatch responses we observed in the spiking activity and local field potentials of the AC and the PFC combined coincided with the time course of the large-scale MMN-like signals reported in the rat brain, thereby linking the microscopic, mesoscopic, and macroscopic levels of automatic deviance detection.
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