Evidence map›Paper›PMID 33347425›Full record

Observational studyAging2020

The impact of physical frailty on the response to inactivated influenza vaccine in older adults.

Krissy K Moehling, Bo Zhai, William E Schwarzmann, Uma R Chandran, Marianna Ortiz, Mary Patricia Nowalk, David Nace, Chyongchiou J Lin, Michael Susick, Min Z Levine and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Observational
  5. Sex-Differential and Non-specific Effects of Vaccines Over the Life Course.Current topics in microbiology and immunology · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Krissy K MoehlingDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Bo ZhaiDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
William E SchwarzmannDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Uma R ChandranDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Marianna OrtizDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Mary Patricia NowalkDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
David NaceDivision of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Chyongchiou J LinDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Michael SusickDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Min Z LevineNational Center for Immunization and Respiratory Diseases, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
John F AlcornDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Richard K ZimmermanDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
University of Pittsburgh · USNational Center for Immunization and Respiratory Diseases · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Outpatient VE for seasonal flu, pandemic flu and RSV in a large, diverse networkU01IP001035 · IP · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIMMERMAN, RICHARD K · 2016 to 2020
$7.8M
Pittsburgh Training Grant in Pediatric Pulmonary MedicineT32HL129949 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Juan Carlos Celedon · 2016 to 2026
$2.9M
NCATS NIH HHS UL1 TR001857NCIRD CDC HHS U01 IP001035NHLBI NIH HHS T32 HL129949
6 · The paper itself

Abstract

Physical frailty's impact on hemagglutination inhibition antibody titers (HAI) and peripheral blood mononuclear cell (PBMC) transcriptional responses after influenza vaccination is unclear. Physical frailty was assessed using the 5-item Fried frailty phenotype in 168 community- and assisted-living adults ≥55 years of age during an observational study. Blood was drawn before, 3, 7, and 28 days post-vaccination with the 2017-2018 inactivated influenza vaccine. HAI response to the A/H1N1 strain was measured at Days 0 and 28 using seropositivity, seroconversion, log

Indexed as

Cell ProliferationAgedAged, 80 and overAntibody FormationAssisted Living FacilitiesCase-Control StudiesFemaleFrailtyHemagglutination Inhibition TestsHumansIndependent LivingInfluenza, HumanInfluenza VaccinesInterferonsInterleukin-8Leukocytes, MononuclearCXCL8 protein, humanInfluenza VaccinesInterferonsInterleukin-8Vaccines, Inactivatedantibody titersfrailtyimmune responseinfluenzaperipheral cell mediated immunity

Identifiers

PMID33347425
PMCPMC7803506
OpenAlexW3109119072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.