Evidence map›Paper›PMID 33347322›Full record

ArticleAnnals of internal medicine2021

College Campuses and COVID-19 Mitigation: Clinical and Economic Value.

Elena Losina, Valia Leifer, Lucia Millham, Christopher Panella, Emily P Hyle, Amir M Mohareb, Anne M Neilan, Andrea L Ciaranello, Pooyan Kazemian, Kenneth A Freedberg

Open access · greenAbstract read
In one paragraph

Article in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  3. A Systematic Review of Economic Evaluations of COVID-19 Interventions: Considerations of Non-Health Impacts and Distributional Issues.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022
    Pooled it
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  5. Cost-Effectiveness of COVID-19 Policy Measures: A Systematic Review.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2021
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Elena LosinaBrigham and Women's Hospital, Harvard Medical School, and Boston University School of Public Health, Boston, Massachusetts (E.L.).ORCID 0000-0002-3424-0892
Valia LeiferBrigham and Women's Hospital, Boston, Massachusetts (V.L.).
Lucia MillhamHarvard Medical School and Massachusetts General Hospital, Boston, Massachusetts (L.M.).
Christopher PanellaMassachusetts General Hospital, Boston, Massachusetts (C.P., A.M.M.).ORCID 0000-0002-6256-507X
Emily P HyleMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.P.H., A.M.N., A.L.C.).
Amir M MoharebMassachusetts General Hospital, Boston, Massachusetts (C.P., A.M.M.).ORCID 0000-0002-3761-6154
Anne M NeilanMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.P.H., A.M.N., A.L.C.).ORCID 0000-0001-7915-4974
Andrea L CiaranelloMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.P.H., A.M.N., A.L.C.).
Pooyan KazemianWeatherhead School of Management, Case Western Reserve University, Cleveland, Ohio (P.K.).ORCID 0000-0002-2846-3862
Kenneth A FreedbergMassachusetts General Hospital, Harvard Medical School, and Harvard T.H. Chan School of Public Health, Boston, Massachusetts (K.A.F.).
Harvard University · USMassachusetts General Hospital · USBoston University · USBrigham and Women's Hospital · USCase Western Reserve University · US

Funding

Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
Development and application of a new simulation model for COVID-19R01AI042006 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Anne Neilan · 1998 to 2026
$12.9M
Optimizing HIV Care in Less Developed CountriesR37AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FREEDBERG, KENNETH ALAN · 2018 to 2024
$6.6M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectivenessK08HD094638 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, ANNE · 2018 to 2023
$936k
NIAID NIH HHS R01 AI042006NIAID NIH HHS R01 AI058736NIAID NIH HHS R37 AI058736NIAMS NIH HHS K24 AR057827NICHD NIH HHS K08 HD094638
6 · The paper itself

Abstract

backgroundColleges in the United States are determining how to operate safely amid the coronavirus disease 2019 (COVID-19) pandemic.

objectiveTo examine the clinical outcomes, cost, and cost-effectiveness of COVID-19 mitigation strategies on college campuses.

designThe Clinical and Economic Analysis of COVID-19 interventions (CEACOV) model, a dynamic microsimulation model, was used to examine alternative mitigation strategies. The CEACOV model tracks infections accrued by students and faculty, accounting for community transmissions. DATA SOURCES: Data from published literature were used to obtain parameters related to COVID-19 and contact-hours. TARGET POPULATION: Undergraduate students and faculty at U.S. colleges. TIME HORIZON: One semester (105 days). PERSPECTIVE: Modified societal.

interventionCOVID-19 mitigation strategies, including social distancing, masks, and routine laboratory screening. OUTCOME MEASURES: Infections among students and faculty per 5000 students and per 1000 faculty, isolation days, tests, costs, cost per infection prevented, and cost per quality-adjusted life-year (QALY). RESULTS OF BASE-CASE ANALYSIS: Among students, mitigation strategies reduced COVID-19 cases from 3746 with no mitigation to 493 with extensive social distancing and masks, and further to 151 when laboratory testing was added among asymptomatic persons every 3 days. Among faculty, these values were 164, 28, and 25 cases, respectively. Costs ranged from about $0.4 million for minimal social distancing to about $0.9 million to $2.1 million for strategies involving laboratory testing ($10 per test), depending on testing frequency. Extensive social distancing with masks cost $170 per infection prevented ($49 200 per QALY) compared with masks alone. Adding routine laboratory testing increased cost per infection prevented to between $2010 and $17 210 (cost per QALY gained, $811 400 to $2 804 600). RESULTS OF SENSITIVITY ANALYSIS: Results were most sensitive to test costs. LIMITATION: Data are from multiple sources.

conclusionExtensive social distancing with a mandatory mask-wearing policy can prevent most COVID-19 cases on college campuses and is very cost-effective. Routine laboratory testing would prevent 96% of infections and require low-cost tests to be economically attractive. PRIMARY FUNDING SOURCE: National Institutes of Health.

Indexed as

UniversitiesAdultCommunicable Disease ControlCost-Benefit AnalysisCOVID-19COVID-19 TestingFemaleHumansMaleMasksMass ScreeningPandemicsPhysical DistancingPneumonia, ViralSARS-CoV-2United States

Identifiers

PMID33347322
PMCPMC7755069
OpenAlexW3117599946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.