SynthesisClinical and translational gastroenterology2020
Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Synthesis in Clinical and translational gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Wearable-Based Monitoring of Autonomic and Gastrointestinal Function in Disorders of Gut-Brain Interaction: A Systematic Review and Meta-Analyses.Neurogastroenterology and motility · 2026Pooled it
- The Prevalence and Nature of Eating and Swallowing Problems in Adults with Fibromyalgia: A Systematic Review.Dysphagia · 2024Pooled it
- Heart Rate Variability-An Index of the Efficacy of Complementary Therapies in Irritable Bowel Syndrome: A Systematic Review.Nutrients · 2022Pooled it
- Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D).Scientific reports · 2026Article
- Article
- Zygosity and autonomic stress reactivity during social exclusion: biofeedback findings from the TwinCord-EDID study.Frontiers in psychiatry · 2026Article
- Remote Patient Monitoring and Connected Technologies in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2025Article
- Efficacy and mechanisms of neuromodulation in the treatment of irritable bowel syndrome.Bioelectronic medicine · 2025Review
- Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2025Article
- Relationship Between High Frequency Component of Heart Rate Variability and Delta EEG Power During Sleep in Women With Irritable Bowel Syndrome Compared to Healthy Women.Biological research for nursing · 2025Article
- Acupuncture and moxibustion in irritable bowel syndrome: a mechanistic exploration from heart rate variability to cardiac metabolism.Frontiers in neurology · 2025Article
- Does Osteopathic Heart-Focused Palpation Modify Heart Rate Variability in Stressed Participants with Musculoskeletal Pain? A Randomised Controlled Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Age Differences in Upper Gastrointestinal Symptoms and Vagal Modulation in Women With Irritable Bowel Syndrome.Biological research for nursing · 2024Article
- Aetiological Understanding of Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Classificatory Analogues: A Systematic Umbrella Review.Clinical psychology in Europe · 2023Review
- Heart Rate Variability and Somatization in Adolescents With Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2023Article
- Bioelectronic medicine for restoring autonomic balance in autoimmune diseases.Gut microbiota and integrative wellness · 2023Article
- Females with Diabetes Mellitus Increased the Incidence of Premenstrual Syndrome.Life (Basel, Switzerland) · 2022Article
- Anatomical Evidence for the Neural Connection from the Emotional Brain to Autonomic Innervation in the Anterior Chamber Structures of the Eye.Current medical science · 2022Article
- Multidimensional Assessment of Interoceptive Abilities, Emotion Processing and the Role of Early Life Stress in Inflammatory Bowel Diseases.Frontiers in psychiatry · 2021Article
- A Pilot Study Using a Smartwatch to Search for Biomarkers of Heart Rate Variability in Active Ulcerative Colitis.Inflammatory intestinal diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIrritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are gastrointestinal pathologies affecting large numbers of the global population and incurring significant healthcare costs. Disruptions in the gut-brain axis occurring in these conditions can lead to increased inflammation, affecting gastrointestinal and autonomic nervous system function. Heart rate variability (HRV) is commonly used to assess the state of the sympathetic and parasympathetic function of the autonomic nervous system, but it remains unclear how HRV measures are associated with gastrointestinal pathologies. Here, we conduct a systematic review of the literature comparing HRV of subjects diagnosed with IBS or IBD to HRV in healthy controls (HC).
methodsWe searched PubMed, Cochrane Library, and CINAHL (EBSCO) for eligible studies up to 2018. We included any study comparing a recognized measure of HRV between a group of patients with either IBS or IBD to a group of matched HC before any intervention. Studies were screened, and data were extracted from included articles using predefined criteria. Random effects meta-analysis was performed for each outcome, with effect size reported as the standardized mean difference.
resultsThere were significant differences between IBD and HC in time domain HRV and significant decreases in high-frequency power measures were also noted, in both IBS and IBD compared with HC. DISCUSSION: Parasympathetic nervous system activity, represented through high-frequency power, seems to be lower in people with IBS and IBD, but conclusions are limited by the small number of studies that provide usable data, methodological heterogeneity, and high risks of bias in primary study methods and measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.