ArticleDrugs in R&D2021
Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety.
Article in Drugs in R&D, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Determinants of the optimal selection of vascular access devices: A systematic review underpinned by the COM-B behavioural model.Journal of advanced nursing · 2025Pooled it
- Spotlight on Clinical In-Use Parameters for Intravenous Infusion of Therapeutic Antibodies: A Systematic Review.Pharmaceutical research · 2025Pooled it
- Extravasation injury management for neonates and children: A systematic review and aggregated case series.Journal of hospital medicine · 2022Pooled it
- Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial.Nursing in critical care · 2026Trial
- Variability in Vascular Access Device Use, Dwell Time and Failure: Insights From Routine Nursing Documentation in a Multicentre Cohort Study.Journal of clinical nursing · 2026Observational
- Article
- Risk Factors for Catheter-Related Thrombosis.Journal of clinical medicine · 2026Article
- Adequacy of the Type of Venous Catheter to the Drug Type and Duration of Treatment: A Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Use of preoperative placement of mini-midline catheters in patients undergoing thoracoscopic lung resection.Scientific reports · 2026Article
- Safe Practices in Intravenous Drug Therapy in Hospitalized Adult Patients: Scoping Review.Revista brasileira de enfermagem · 2026Article
- Indian Expert Consensus on the Selection of Vascular Access Devices in Oncology Patients.Indian journal of surgical oncology · 2025Article
- Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy.Journal of medicinal chemistry · 2025Article
- Design research on a smart infusion device to reduce medical workload and enhance patient safety.Scientific reports · 2025Article
- Article
- Stability study of common vasoactive drugs diluted in five types of solutions.Frontiers in pharmacology · 2025Article
- Parenteral morphine and oxycodone mixtures administered in specialised palliative and hospice care units: A retrospective medical record review.Palliative care and social practice · 2025Article
- Efficacy ofJournal of inflammation research · 2025Article
- Standardisation of intravenous infusion therapy for paediatrics: big challenges for the little patients.European journal of hospital pharmacy : science and practice · 2024Article
- The First Use of a Midline Catheter in Outpatient Pain Management.Healthcare (Basel, Switzerland) · 2024Article
- Classification of non-antineoplastic intravenously administered drugs according to their toxicity risk: the path towards safe drug administration.European journal of hospital pharmacy : science and practice · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
32 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntravenous drug administration is associated with potential complications, such as phlebitis. The physiochemical characteristics of the infusate play a very important role in some of these problems.
aimThe aim of this study was to standardize the dilutions of intravenous drugs most commonly used in hospitalized adult patients and to characterize their pH, osmolarity and cytotoxic nature to better guide the selection of the most appropriate vascular access.
methodsThe project was conducted in three phases: (i) standardization of intravenous therapy, which was conducted using a modified double-round Delphi method; (ii) characterization of the dilutions agreed on in the previous phase by means of determining the osmolarity and pH of each of the agreed concentrations, and recording the vesicant nature based on the information in literature; and (iii) algorithm proposal for selecting the most appropriate vascular access, taking into account the information gathered in the previous phases.
resultsIn total, 112 drugs were standardized and 307 different admixtures were assessed for pH, osmolarity and vesicant nature. Of these, 123 admixtures (40%), had osmolarity values >600 mOsm/L, pH < 4 or > 9, or were classified as vesicants. In these cases, selection of the most suitable route of infusion and vascular access device is crucial to minimize the risk of phlebitis-type complications.
conclusionsIncreasing safety of intravenous therapy should be a priority in the healthcare settings. Knowing the characteristics of drugs to assess the risk involved in their administration related to their physicochemical nature may be useful to guide decision making regarding the most appropriate vascular access and devices.
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