ArticleClinical neuroradiology2021
Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors.
Article in Clinical neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Survival, Recorded Disability, and Neurorehabilitation After Advanced Endovascular Stroke Care in Kazakhstan: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Sex-Based Efficacy of Endovascular Thrombectomy Techniques in LVO Stroke: A Multicenter Registry Analysis.Stroke · 2026Article
- Sex differences in stroke prognosis across reperfusion strategies: implications for prevention and quality of life.GeroScience · 2026Article
- Sex Differences in Prognostic Markers: Exploring Outcome Variability After Mechanical Thrombectomy in Large Vessel Occlusion Stroke.Journal of clinical medicine · 2025Article
- Sex-Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke-Analyses From the German Stroke Registry-Endovascular Treatment.European journal of neurology · 2025Observational
- Sex is not an independent predictor of 90-day outcomes after mechanical thrombectomy in Chinese patients with acute ischemic stroke: a prospective cohort study.Frontiers in surgery · 2025Article
- Sex-Based Analysis of Treatment, Time Metrics, and Outcomes in Acute Ischemic Stroke Patients Treated in the Netherlands.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Sex-based differences in outcomes following endovascular therapy for anterior circulation large vessel occlusion: a pooled analysis of DEVT, RESCUE BT, and MARVEL trials.Frontiers in neurology · 2025Article
- Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy.European stroke journal · 2024Article
- Sex Disparities in the Direct Cost and Management of Stroke: A Population-Based Retrospective Study.Healthcare (Basel, Switzerland) · 2024Article
- Sex-Specific Effects of Endovascular Treatment in Large-Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2024Article
- Impact of Sex on Thrombectomy Outcomes in Ischemic Stroke: A Propensity Score-Matched Study, Systematic Review, and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Sex differences in outcomes of endovascular therapy for acute vertebrobasilar occlusion: data from ANGEL-ACT Registry.Journal of neurology · 2024Article
- The evolution of acute stroke care in Germany from 2019 to 2021: analysis of nation-wide administrative datasets.Neurological research and practice · 2024Article
- Predicting 90-Day Prognosis in Ischemic Stroke Patients Post Thrombolysis Using Machine Learning.Journal of personalized medicine · 2023Article
- Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia.European stroke journal · 2023Article
- Adjusted horizontal stacked bar graphs ("Grotta bars") for consistent presentation of observational stroke study results.European stroke journal · 2023Article
- Sex and Gender Differences in Stroke and Their Practical Implications in Acute Care.Journal of stroke · 2023Review
- Clinical outcome and outcome prediction of octogenarians with acute basilar artery occlusion and endovascular stroke treatment compared to younger patients.Frontiers in neurology · 2023Article
- Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study.European stroke journal · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to analyze sex differences in outcome after thrombectomy for acute ischemic stroke in clinical practice in a large prospective multicenter registry.
methodsData of consecutive stroke patients treated with thrombectomy (June 2015-April 2018) derived from an industry-independent registry (German Stroke Registry-Endovascular Treatment) were prospectively analyzed. Multivariable binary logistic regression analyses were applied to determine whether sex is a predictor of functional independence outcome (defined as a modified Rankin scale [mRS] 0-2) 90 days after stroke.
resultsIn total, 2316 patients were included in the analysis, 1170 (50.5%) were female and 1146 (49.5%) were male. Women were older (median age 78 vs. 72 years; p < 0.001) and more frequently had a prestroke functional impairment defined by mRS >1 (24.8% vs. 14.1%; p < 0.001). In unadjusted analyses, independent outcome at 90 days was less frequent in women (33.2%) than men (40.6%; p < 0.001). Likewise, mortality was higher in women than in men (30.7% vs. 26.4%; p = 0.024). In adjusted regression analyses, however, sex was not associated with outcome. Lower age, a lower baseline National Institutes of Health Stroke Scale score, a higher Alberta Stroke Program Early CT score, prestroke functional independence, successful reperfusion, and concomitant intravenous thrombolysis therapy predicted independent outcome.
conclusionWomen showed a worse functional outcome after thrombectomy for acute ischemic stroke in clinical practice; however, after adjustment for crucial confounders sex was not a predictor of outcome. The difference in outcome thus appears to result from differences in confounding factors such as age and prestroke functional status.
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