Evidence map›Paper›PMID 33345703›Full record

SynthesisGut microbes2020

Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than

Jessica Emily Green, Jessica A Davis, Michael Berk, Christopher Hair, Amy Loughman, David Castle, Eugene Athan, Andrew A Nierenberg, John F Cryan, Felice Jacka and 1 more

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07509346 (Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Fecal Microbiota Transplantation Versus Standard Treatment in Patients With Recurrent Non-Obstructive Acute Cholangitis - COLANBIOTA Trial), which is not on this map. Cited by 106 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 6 pooled it
2.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07509346 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Fecal Microbiota Transplantation Versus Standard Treatment in Patients With Recurrent Non-Obstructive Acute Cholangitis - COLANBIOTA Trial

TypeinterventionalSponsorPuerta de Hierro University HospitalRan2026 to 2029Enrolled44ConditionsCholangitis Acute, RecurrenceArmsFecal Microbial Transplantation
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 6 syntheses or guidelines pooled it, 147 citations in OpenAlex.

  1. Pooled it
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  6. Guideline
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jessica Emily GreenIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.
Jessica A DavisIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.
Michael BerkIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.ORCID 0000-0002-5554-6946
Christopher HairBarwon Health , Geelong, Australia.
Amy LoughmanIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.ORCID 0000-0002-0257-1443
David CastleDepartment of Psychiatry, University of Melbourne , Parkville, Australia.ORCID 0000-0002-3075-1580
Eugene AthanIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.
Andrew A NierenbergDepartment of Psychiatry, Dauten Family Center for Bipolar Treatment Innovation , Boston, MA, USA.
John F CryanDepartment of Anatomy and Neuroscience, University College Cork and APC Microbiome , Ireland.ORCID 0000-0001-5887-2723
Felice JackaIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.ORCID 0000-0002-9825-0328
Wolfgang MarxIMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Deakin University , Geelong, Australia.
Barwon Health · AUHarvard University · USThe University of Melbourne · AUUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal microbiome has been identified as a key modifier for a variety of health conditions. Fecal Microbiota Transplantation (FMT) has emerged as a fast, safe, and effective means by which to modify the intestinal microbiome and potentially treat a variety of health conditions. Despite extensive research of FMT for CDI, there is a lack of clarity informed by systematic synthesis of data regarding the safety and efficacy of FMT for other health conditions. This systematic review used PRISMA guidelines and was prospectively registered with PROSPERO (CRD42018104243). In March 2020, a search of MEDLINE, EMBASE, and PsycINFO was conducted. We identified 26 eligible studies. A meta-analysis of FMT for active Ulcerative Colitis (UC) showed that FMT significantly improved rates of clinical remission (OR = 3.634, 95% CI = 1.940 to 6.808, I

Indexed as

Colitis, UlcerativeDrug Resistance, BacterialFecal Microbiota TransplantationGastrointestinal MicrobiomeHumansIrritable Bowel SyndromeLiver DiseasesMetabolic SyndromeObesityTreatment OutcomedepressionFecal microbiota transplantation clostridium difficileirritable bowel syndromemental disordermeta-analysismicrobiomeneurosciencepsychiatryRCTsystematic reviewulcerative colitis

Identifiers

PMID33345703
PMCPMC7757860
OpenAlexW3115119009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.