Evidence map›Paper›PMID 33345667›Full record

ArticleThe Journal of international medical research2020

A polymorphism in the 3'-untranslated region of the matrix metallopeptidase 9 gene is associated with susceptibility to idiopathic calcium nephrolithiasis in the Chinese population.

Qiang Bu, Yu Zhu, Qiao-Yun Chen, Hao Li, Yan Pan

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. A functionalFrontiers in medicine · 2023
    Article
  3. Effects ofFrontiers in cardiovascular medicine · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Qiang BuDepartment of Urology, Danyang People's Hospital, Danyang, Jiangsu, P.R. China.
Yu ZhuDepartment of Anaesthesiology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Jiangsu, P.R. China.
Qiao-Yun ChenDepartment of Central Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Hao LiDepartment of Clinical Laboratory, Taixing People's Hospital Affiliated to Bengbu Medical College, Taixing, Jiangsu, P.R. China.
Yan PanDepartment of Clinical Laboratory, Lianshui County People's Hospital, Lianshui, Jiangsu, P.R. China.ORCID https://orcid.org/0000-0001-8764-9678
Bengbu Medical College · CNFuyang City People's Hospital · CNJiangsu University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether single nucleotide polymorphisms (SNPs) in the 3' untranslated region (UTR) of the matrix metallopeptidase 9 gene (

methodsA total of 428 patients with kidney stone disease (KSD) and 450 control individuals were enrolled. Three

resultsThe rs1056628 CC genotype was significantly increased in KSD patients compared with controls (CC vs AA: odds ratio [OR] = 2.279, 95% confidence interval [CI] = 1.048-4.956). The rs1056628 C allele frequency was higher in KSD patients than controls. The increased KSD risks associated with rs1056628 were more evident in individuals aged <30 years (OR = 3.504, 95% CI = 1.102-11.139) and men (OR = 2.522, 95% CI = 1.004-6.334). mRNA and protein levels of

conclusionThis study demonstrates that

Indexed as

CalciumMatrix Metalloproteinase 9MicroRNAsNephrolithiasisUric Acid3' Untranslated RegionsAdultAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHEK293 CellsHumans3' Untranslated RegionsCalciumMatrix Metalloproteinase 9MetalloproteasesMicroRNAsMIRN491 microRNA, humanMMP9 protein, humanUric Acidcalcium oxalateKidney stone diseasematrix metalloproteinase 9microRNApolymorphismrs1056628

Identifiers

PMID33345667
PMCPMC7756046
OpenAlexW3116787308

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.