Evidence map›Paper›PMID 33345554›Full record

ArticleThe American surgeon2021

Patient Comorbidities Drive High Mortality Rates Associated with Major Liver Resections Irrespective of Hospital Volume.

Laurence P Diggs, John G Aversa, Timothy L Wiemken, Sean P Martin, Justin A Drake, Samantha M Ruff, Michael M Wach, Zachary J Brown, Andrew M Blakely, Jeremy L Davis and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American surgeon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Laurence P DiggsSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
John G AversaSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Timothy L WiemkenSaint Louis University Center for Health Outcomes Research (SLUCOR), St. Louis, MO, USA.
Sean P MartinSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Justin A DrakeSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Samantha M RuffSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Michael M WachSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Zachary J BrownSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Andrew M BlakelySurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Jeremy L DavisSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
Carrie LuuDepartment of Surgery, Division of General Surgery, 12274Saint Louis University Hospital, St. Louis, MO, USA.
Jonathan M HernandezSurgical Oncology Program, Center for Cancer Research, National Institutes of Health, 3421National Cancer Institute, Bethesda, MD, USA.
National Institutes of Health · USCenter for Cancer Research · USSaint Louis University Hospital · USNational Cancer Institute · USSaint Louis University · US

Funding

Evaluating outcomes for patients with primary-metastatic gastrointestinal cancerZIABC011861 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HERNANDEZ, JONATHAN · 2019 to 2025
$166k
Intramural NIH HHS ZIA BC011861
6 · The paper itself

Abstract

introductionMajor hepatectomies are utilized to manage primary hepatic malignancies. Reports from high-volume centers (HVCs) with minimal perioperative mortality focus on multiple aspects of perioperative care, although patient-specific factors remain unelucidated. We identified patient factors associated with outcomes and examined whether these contribute to survival differences.

methodsWe queried the National Cancer Database (2006-2015) for patients with primary liver malignancies managed with major hepatectomy. Facilities were dichotomized by volume (high volume: >15 hepatectomies/year). Perioperative outcomes were compared based on patient demographic and clinical characteristics as well as center volume.

results4263 patients were included with 78.5% receiving care in low-volume centers (LVCs). 90-day postoperative mortality was higher in LVCs vs. HVCs (12% vs. 7.5%;

conclusionReduced perioperative mortality following major hepatectomy in HVCs is driven by optimal management of patients with low CDS. However, nearly 1 in 5 patients who undergo major hepatectomies have a high CDS and approximately 15% of them succumb in the perioperative period irrespective of the treating centers' experience.

Indexed as

Hospitals, High-VolumeHospitals, Low-VolumeAgedDatabases, FactualFemaleHepatectomyHospital MortalityHumansLiver DiseasesMaleMiddle AgedRetrospective StudiesSocioeconomic FactorsTreatment OutcomeUnited Statescenter volumecomorbidityliver malignancymajor hepatectomyperioperative malignancy

Identifiers

PMID33345554
PMCPMC9927630
OpenAlexW3114964380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.